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A New Ir-NHC Catalyst for Signal Amplification by Reversible Exchange in D2O

机译：新型Ir-NHC催化剂，用于D2O中可逆交换的信号放大

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摘要

NMR signal amplification by reversible exchange (SABRE) has been observed for pyridine, methyl nicotinate, N-methylnicotinamide, and nicotinamide in D2O with the new catalyst [Ir(Cl)(IDEG)(COD)] (IDEG=1,3-bis(3,4,5-tris(diethyleneglycol)benzyl)imidazole-2-ylidene). During the activation and hyperpolarization steps, exclusively D2O was used, resulting in the first fully biocompatible SABRE system. Hyperpolarized H-1 substrate signals were observed at 42.5 MHz upon pressurizing the solution with parahydrogen at close to the Earth's magnetic field, at concentrations yielding barely detectable thermal signals. Moreover, 42-, 26-, 22-, and 9-fold enhancements were observed for nicotinamide, pyridine, methyl nicotinate, and N-methylnicotinamide, respectively, in conventional 300 MHz studies. This research opens up new opportunities in afield in which SABRE has hitherto primarily been conducted in CD,OD. This system uses simple hardware, leaves the substrate unaltered, and shows that SABRE is potentially suitable for clinical purposes.
机译：用新催化剂[Ir（Cl）（IDEG）（COD）]在D2O中观察到吡啶，烟酸甲酯，N-甲基烟酰胺和烟酰胺的可逆交换（SABRE）NMR信号放大（IDEG = 1,3-bis （3,4,5-三（二乙二醇）苄基）咪唑-2-亚烷基）。在激活和超极化步骤期间，仅使用D2O，从而形成了第一个完全生物相容的SABRE系统。在接近地球磁场的条件下，用对氢对溶液加压后，在42.5 MHz处观察到超极化的H-1底物信号，其浓度几乎无法检测到热信号。此外，在常规的300 MHz研究中，烟酰胺，吡啶，烟酸甲酯和N-甲基烟酰胺分别提高了42倍，26倍，22倍和9倍。这项研究在迄今为止主要以CD，OD进行SABER的领域开辟了新的机会。该系统使用简单的硬件，使基材保持不变，并表明SABRE可能适合于临床目的。

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