Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

Ubeda Monica Munoz; Carniato Fabio; Catanzaro Valeria; Padovan Sergio; Grange Cristina; Porta Stefano; Carrera Carla; Tei Lorenzo; Digilio Giuseppe

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Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

机译：d修饰的二氧化硅微球作为氧化还原反应性MRI探针，在细胞治疗随访中的应用

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The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.

机译：细胞移植物中的氧化还原微环境可以被认为是评估移植物是否具有代谢活性或低氧的指标。我们提出了基于多孔二氧化硅微粒的氧化还原反应性MRI探头，其表面已通过二硫键被Gd-螯合物修饰。此类微粒被设计为散布在生物相容性水凝胶内的治疗性细胞中。水凝胶中还原条件的发作与Gd清除率的增加平行，这可以通过MRI检测到。

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《Chemistry: A European journal》 |2016年第23期|共5页
作者
Ubeda Monica Munoz; Carniato Fabio; Catanzaro Valeria; Padovan Sergio; Grange Cristina; Porta Stefano; Carrera Carla; Tei Lorenzo; Digilio Giuseppe;
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正文语种 eng
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cellular imaging; gadolinium; magnetic resonance imaging; redox-responsive; silica microspheres;

机译：细胞成像ga磁共振成像氧化还原反应二氧化硅微球;

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1. Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up [J] . Ubeda Monica Munoz, Carniato Fabio, Catanzaro Valeria, Chemistry: A European journal . 2016,第23期

机译：d修饰的二氧化硅微球作为氧化还原反应性MRI探针，在细胞治疗随访中的应用
2. Probing Photocatalytic Active Sites on a Single Titanosilicate Zeolite with a Redox-Responsive Fluorescent Dye† [J] . li id=au1Takashi Tachikawa Dr. li id=au2Soichiro Yamashita li id=au3Tetsuro Majima Prof.#x2005, Dr. Angewandte Chemie . 2010,第2期

机译：用氧化还原响应荧光染料在单个钛硅酸盐沸石上探测光催化活性位†
3. Probing Photocatalytic Active Sites on a Single Titanosilicate Zeolite with a Redox-Responsive Fluorescent Dye† [J] . Takashi Tachikawa Dr. Soichiro Yamashita Tetsuro Majima Prof.#x2005, Dr. Angewandte Chemie International Edition . 2010,第2期

机译：用氧化还原响应荧光染料在单个钛硅酸盐沸石上探测光催化活性位†
4. Surface modification of injectable microspheres for cell therapy applications [C] . Abdulrahman Baki, Omar Qutachi, Toby Gould, European conference on biomaterials . 2014

机译：用于细胞疗法的可注射微球的表面改性
5. Synthesis and Application of Organic DOTA-Based Probes for Imaging Tumor Cells and Cancer Therapy. [D] . Eskandari, Vahid. 2011

机译：用于肿瘤细胞成像和癌症治疗的基于有机DOTA的探针的合成与应用。
6. Genetic engineered molecular imaging probes for applications in cell therapy: emphasis on MRI approach [O] . In K Cho, Silun Wang, Hui Mao, 2016

机译：基因工程分子成像探针在细胞治疗中的应用：重点放在MRI方法上
7. Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy [O] . Shanka Walia, Amitabha Acharya 2015

机译：用于治疗诊断的二氧化硅微/纳米球：从双峰mRI和荧光成像探针到癌症治疗

Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

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