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首页> 外文期刊>Chemistry: A European journal >In Situ Loading of Drugs into Mesoporous Silica SBA-15
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In Situ Loading of Drugs into Mesoporous Silica SBA-15

机译：将药物原位装载到介孔二氧化硅SBA-15中

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摘要

In a new strategy for loading drugs into mesoporous silica, a hydrophilic (heparin) or hydrophobic drug (ibuprofen) is encapsulated directly in a one-pot synthesis by evaporation-induced self-assembly. In situ drug loading significantly cuts down the preparation time and dramatically increases the loaded amount and released fraction of the drug, and appropriate drug additives favor a mesoporous structure of the vessels. Drug loading was verified by FTIR spectroscopy and release tests, which revealed much longer release with a larger amount of heparin or ibuprofen compared to postloaded SBA-15. Besides, the in vitro anticoagulation properties of the released heparin and the biocompatibility of the vessels were carefully assessed, including activated partial thromboplastin time, thrombin time, hemolysis, platelet adhesion experiments, and the morphologies of red blood cells. A concept of new drug-release agents with soft core and hard shell is proposed and offers guidance for the design of novel drug-delivery systems.
机译：在一种将药物加载到中孔二氧化硅中的新策略中，通过蒸发诱导的自组装将亲水性（肝素）或疏水性药物（布洛芬）直接封装在一个锅中。原位载药大大减少了制备时间，并显着增加了载药量和释放的药物分数，并且合适的药物添加剂有利于血管的中孔结构。通过FTIR光谱和释放测试验证了载药量，与后载SBA-15相比，用大量肝素或布洛芬释放的时间更长。此外，还仔细评估了释放的肝素的体外抗凝特性和血管的生物相容性，包括活化的部分凝血活酶时间，凝血酶时间，溶血，血小板粘附实验以及红细胞的形态。提出了具有软核和硬壳的新型药物释放剂的概念，并为新型药物传递系统的设计提供了指导。

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