Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines

Kato Naoya; Shirai Tomohiko; Yamamoto Yasunori

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Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines

机译：铑催化脂肪亚胺的对映选择性丙烯酸化

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Chiral rhodium(I)-catalyzed highly enantioselective arylation of aliphatic N-sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched a-branched amines (up to 99% ee). In addition, this system enables efficient synthesis of (+)-NPS R-568 and Cinacalcet which are calcimimetic agents.

机译：已经开发出手性铑（I）催化的脂肪族N-磺酰基醛亚胺与芳基硼酸的高度对映选择性芳基化。通过使用铑/双（亚磷酰胺）催化剂实现对映异构体富集的α-支化胺（高达99％ee）的转化。另外，该系统能够有效合成拟钙剂（+）-NPS R-568和西那卡塞。

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《Chemistry: A European journal》 |2016年第23期|共4页
作者
Kato Naoya; Shirai Tomohiko; Yamamoto Yasunori;
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正文语种 eng
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asymmetric arylation; cationic rhodium; imines; phosphoramidite; alpha-branched amine;

机译：不对称芳基化;阳离子铑;亚胺;亚磷酰胺;α-支化胺;

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1. Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines [J] . Kato Naoya, Shirai Tomohiko, Yamamoto Yasunori Chemistry: A European journal . 2016,第23期

机译：铑催化脂肪亚胺的对映选择性丙烯酸化
2. Rhodium-catalyzed asymmetric arylation of N -(tert -butanesulfinyl)imines with sodium tetraarylborates [J] . Reddy L.R., Gupta A.P., Villhauer E., The Journal of Organic Chemistry . 2012,第2期

机译：铑催化的N-（叔丁烷亚磺酰基）亚胺与四芳基硼酸钠的不对称芳基化
3. Rhodium-catalyzed asymmetric arylation of azomethine imines [J] . Shintani R., Soh Y.-T., Hayashi T. Organic letters . 2010,第18期

机译：铑催化的偶氮甲亚胺的不对称芳基化
4. Rhodium-Catalyzed Arylation of Ketones, Imines, and Nitriles Using Arylboron Compounds [C] . Tetsuya Satoh, Kenji Ueura, Sawako Miyamura Symposium on Organometallic Chemistry . 2006

机译：使用芳基苯化合物催化酮催化酮，亚胺和腈的芳基化合物
5. Enantioselective rhodium-catalyzed [2+2+2] and [4+2+2] cycloaddition reactions of alkenyl heterocumulenes: Applications to alkaloid synthesis [D] . Yu, Robert Tzu Hsiang 2009

机译：对映体选择性铑催化的烯基杂枯烯的[2 + 2 + 2]和[4 + 2 + 2]环加成反应：在生物碱合成中的应用
6. Enantioselective Rhodium-Catalyzed 4+2 Cycloaddition of Alpha Beta-Unsaturated Imines and Isocyanates [O] . Kevin M. Oberg, Tomislav Rovis -1

机译：不对称铑催化4 + 2αβ-不饱和亚胺和异氰酸酯的环加成
7. Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines [O] . Kato, Naoya, Shirai, Tomohiko, Yamamoto, Yasunori 2016

机译：铑催化的脂肪亚胺的对映选择性丙烯酸化

Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines

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