Rhodium- and Iridium-Catalyzed Asymmetric Addition of Optically Pure P-Chiral H-Phosphinates to Aldehydes Leading to Optically Active alpha-Hydroxyphosphinates

Li Qiang; Chen Tieqiao; Xu Qing; Han Li-Biao

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Rhodium- and Iridium-Catalyzed Asymmetric Addition of Optically Pure P-Chiral H-Phosphinates to Aldehydes Leading to Optically Active alpha-Hydroxyphosphinates

机译：铑和铱催化的光学纯的P-手性H-膦酸酯向醛的不对称加成反应导致光学活性的α-羟基次膦酸酯

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Optically active alpha-hydroxyphosphinates with both C- and P-stereogenic centers are obtained by rhodium- or iridium-catalyzed substrate-directed stereoselective addition of the optically pure H-phosphinates to aldehydes. The reaction most probably proceeds by a transition- metal-catalyzed mechanism with hydridometal complexes as key intermediates in the catalytic cycle.

机译：通过将光学纯的H-次膦酸酯与醛催化的铑或铱催化的底物定向的立体选择加成反应，获得具有C-和P-立体异构中心的旋光性α-羟基次膦酸酯。该反应最有可能通过过渡金属催化的机理进行，其中氢化金属络合物作为催化循环中的关键中间体。

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《Chemistry: A European journal》 |2016年第18期|共5页
作者
Li Qiang; Chen Tieqiao; Xu Qing; Han Li-Biao;
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正文语种 eng
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aldehydes; hydroxyphosphinates; iridium catalyst; phosphinates; rhodium catalyst; stereoselective addition;

机译：醛;羟基次膦酸盐;铱催化剂;次膦酸盐;铑催化剂;立体选择性加成;

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1. Rhodium- and Iridium-Catalyzed Asymmetric Addition of Optically Pure P-Chiral H-Phosphinates to Aldehydes Leading to Optically Active alpha-Hydroxyphosphinates [J] . Li Qiang, Chen Tieqiao, Xu Qing, Chemistry: A European journal . 2016,第18期

机译：铑和铱催化的光学纯的P-手性H-膦酸酯向醛的不对称加成反应导致光学活性的α-羟基次膦酸酯
2. Asymmetric nucleophilic addition reactions of aldehydes with optically active dithioacetals and their application to optically active #alpha-hydroxy ketone synthesis [J] . Hideo Taka, Ken-ichi Fujita, Akihiro Oishi, Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2002,第8期

机译：醛与旋光性二硫缩醛的不对称亲核加成反应及其在旋光性α-羟基酮合成中的应用
3. Chiral polymers in asymmetric catalysis: an optically active polybinaphthyl-Ti(IV) catalyst for an asymmetric alkyl addition to aldehydes [J] . Hong-Bin Yu, Xiao-Fan Zheng, Qiao-Sheng Hu, Polymer Preprints . 1999,第1期

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4. Preparation and Use of Optically Active Multimetallic Complexes of P-Chiral Tetraphosphine [C] . Keiji Yashio, Hidetoshi Takahashi, Kosuke Katagiri Symposium on Organometallic Chemistry . 2007

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机译：高映选择性迈克尔向α，β-不饱和醛磷酸盐加入α，β-不饱和醛硼酸盐：有效进入光学活性γ-硝基醛及其烯醇甲硅烷基醚。

Rhodium- and Iridium-Catalyzed Asymmetric Addition of Optically Pure P-Chiral H-Phosphinates to Aldehydes Leading to Optically Active alpha-Hydroxyphosphinates

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