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首页> 外文期刊>Chemistry: A European journal >Coordination-Driven Self-Assembly and Anticancer Potency Studies of Ruthenium-Cobalt-Based Heterometallic Rectangles
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Coordination-Driven Self-Assembly and Anticancer Potency Studies of Ruthenium-Cobalt-Based Heterometallic Rectangles

机译：钴钴基异金属矩形的配位驱动自组装和抗癌能力研究

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摘要

Three new cobalt-ruthenium heterometallic molecular rectangles, 1-3, were synthesized through the coordination-driven self-assembly of a new cobalt sandwich donor, (eta(5)-Cp)Co[C-4-trans-Ph-2(4-Py)(2)] (L; Cp: cyclopentyl; Py: pyridine), and one of three dinuclear precursors, [(p-cymene)(2)Ru-2(OO boolean AND OO)(2)Cl-2] [OO boolean AND OO: oxalato (A1), 5,8-dioxido-1,4-naphthoquinone (A(2)), or 6,11-dioxido-5,12-naphthacenedione (A(3))]. All of the self-assembled architectures were isolated in very good yield (92-94%) and were fully characterized by spectroscopic analysis; the molecular structures of 2 and 3 were determined by single-crystal X-ray diffraction analysis. The anticancer activities of bimetallic rectangles 1-3 were evaluated with a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, an autophagy assay, and Western blotting. Rectangles 1-3 showed higher cytotoxicity than doxorubicin in AGS human gastric carcinoma cells. In addition, the autophagic activities and apoptotic cell death ratios were increased in AGS cells by treatment with 1-3; the rectangles induced autophagosome formation by promoting LC3-I to LC3-II conversion and apoptotic cell death by increasing caspase-3/7 activity. Our results suggest that rectangles 1-3 induce gastric cancer cell death by modulating autophagy and apoptosis and that they have potential use as agents for the treatment of human gastric cancer.
机译：通过新的钴三明治供体（eta（5）-Cp）Co [C-4-trans-Ph-2（）的配位驱动自组装合成了三个新的钴-钌异金属分子矩形1-3 4-Py）（2）]（L; Cp：环戊基; Py：吡啶），和三种双核前体之一，[（p-cymene）（2）Ru-2（OO布尔AND OO）（2）Cl- 2] [OO布尔值和OO：草酸（A1），5,8-二氧化物-1,4-萘醌（A（2））或6,11-二氧化物-5,12-萘二酮（A（3））]] 。所有自组装的体系结构均以极高的产率（92-94％）分离，并通过光谱分析进行了全面表征。通过单晶X射线衍射分析确定2和3的分子结构。用3- [4,5-二甲基噻唑-2-基] -2,5-二苯基四氮唑溴化物（MTT）测定，自噬测定和Western印迹评估双金属矩形1-3的抗癌活性。矩形1-3在AGS人胃癌细胞中显示出比阿霉素更高的细胞毒性。另外，通过1-3处理，AGS细胞的自噬活性和凋亡细胞死亡率增加。矩形通过增加caspase-3 / 7活性促进LC3-I到LC3-II的转化和凋亡细胞的死亡，从而诱导自噬体的形成。我们的结果表明，矩形1-3通过调节自噬和凋亡来诱导胃癌细胞死亡，并且它们有潜力用作治疗人胃癌的药物。

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