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首页> 外文期刊>Chemistry: A European journal >Engyodontochones, Antibiotic Polyketides from the Marine Fungus Engyodontium album Strain LF069
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Engyodontochones, Antibiotic Polyketides from the Marine Fungus Engyodontium album Strain LF069

机译：Engyodontochones，从海洋真菌Engyodontium专辑应变LF069抗生素多酮化合物

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摘要

Six new (2, 4-8) and two known polyketides with a basic structure of an anthraquinone-xanthone were isolated from mycelia and culture broth of the fungus Engyodontium album strain LF069. The structures and relative configurations of these compounds were established by spectroscopic means, and their absolute configurations were defined mainly by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Compounds 2 and 4-8 were given the trivial names engyodontochone A (2) and B-F (4-8). Compounds 5-8 represent the first example of a 23,28 seco-beticolin carbon skeleton. The relative and absolute configurations of two known substances JBIR-97/98 (1) and JBIR-99 (3) were determined for the first time. All isolated compounds were subjected to bioactivity assays. Compounds 1-4 exhibited inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) that was 10-fold stronger than chloramphenicol.
机译：从真菌Engyodontium album菌株LF069的菌丝体和培养液中分离出六个新的（2、4-8）和两个具有蒽醌-蒽酮基本结构的已知聚酮化合物。通过光谱学方法确定了这些化合物的结构和相对构型，其绝对构型主要通过比较计算的量子化学TDDFT和实验ECD谱来确定。化合物2和4-8的通用名称为engyodontochone A（2）和B-F（4-8）。化合物5-8代表23，28癸二酚的碳骨架的第一个例子。首次确定了两种已知物质JBIR-97 / 98（1）和JBIR-99（3）的相对和绝对构型。对所有分离的化合物进行生物活性测定。化合物1-4对耐甲氧西林的金黄色葡萄球菌（MRSA）的抑制活性比氯霉素强10倍。

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