Synthesis of beta-1,4-Linked Galactan Side-Chains of Rhamnogalacturonan I

Andersen Mathias C. F.; Kracun Stjepan K.; Rydahl Maja G.; Willats William G. T.; Clausen Mads H.

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Synthesis of beta-1,4-Linked Galactan Side-Chains of Rhamnogalacturonan I

机译：鼠李糖半乳糖醛酸I的β-1,4-连接半乳聚糖侧链的合成

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摘要

The synthesis of linear- and (1 -> 6)-branched beta-(1 -> 4)-D-galactans, side-chains of the pectic polysaccharide rhamnogalacturonan I is described. The strategy relies on iterative couplings of n-pentenyl disaccharides followed by a late stage glycosylation of a common hexasaccharide core. Reaction with a covalent linker and immobilization on N-hydroxysuccinimide (NHS)-modified glass surfaces allows the generation of carbohydrate microarrays. The glycan arrays enable the study of protein-carbohydrate interactions in a high-throughput fashion, demonstrated herein with binding studies of mAbs and a CBM.

机译：描述了果胶多糖鼠李糖半乳糖醛酸聚糖I的侧链和直链和（1→6）支链的β-（1→4）-D-半乳聚糖的合成。该策略依赖于正戊烯基二糖的迭代偶联，随后是常见六糖核心的晚期糖基化。与共价接头反应并固定在N-羟基琥珀酰亚胺（NHS）修饰的玻璃表面上，可以生成碳水化合物微阵列。聚糖阵列使得能够以高通量的方式研究蛋白质与碳水化合物的相互作用，本文通过mAb和CBM的结合研究证明了这一点。

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《Chemistry: A European journal》 |2016年第33期|共6页
作者
Andersen Mathias C. F.; Kracun Stjepan K.; Rydahl Maja G.; Willats William G. T.; Clausen Mads H.;
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正文语种 eng
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carbohydrates; glycosylation; oligosaccharides; plant cell walls; rhamnogalacturonan;

机译：碳水化合物;糖基化;低聚糖;植物细胞壁;鼠李半乳糖醛酸;

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1. Synthesis of beta-1,4-Linked Galactan Side-Chains of Rhamnogalacturonan I [J] . Andersen Mathias C. F., Kracun Stjepan K., Rydahl Maja G., Chemistry: A European journal . 2016,第33期

机译：鼠李糖半乳糖醛酸I的β-1,4-连接半乳聚糖侧链的合成
2. Catalytic properties and mode of action of three endo-beta-glucanases from Talaromyces emersonii on soluble beta-1,4- and beta-1,3;1,4-linked glucans [J] . McCarthy T., Hanniffy O., Savage AV., International Journal of Biological Macromolecules: Structure, Function and Interactions . 2003,第1a3期

机译：拟南芥（Talaromyces emersonii）的三种内切β-葡聚糖酶对可溶性β-1,4-和β-1,3; 1,4连接的葡聚糖的催化特性和作用方式
3. Investigating the binding of beta-1,4-galactan to Bacillus licheniformis beta-1,4-galactanase by crystallography and computational modeling. [J] . Le Nours J, De Maria L, Welner D, Proteins: Structure, Function, and Genetics . 2009,第4期

机译：通过晶体学和计算模型研究β-1,4-半乳聚糖与地衣芽孢杆菌β-1,4-半乳聚糖酶的结合。
4. SYNTHESIS OF BRANCHED OLIGOSACCHARIDES RELATED TO THE PECTIC RHAMNOGALACTURONAN I POLYSACCHARIDE [C] . Cecilia Romano, Shahid I. Awan, Mads H. Clausen International Carbohydrate Symposium . 2018

机译：与果皮菌肌肌肌酐I多糖相关的支链寡糖的合成
5. N-chain glucose processing and proper beta-1,3-glucan biosynthesis are required for normal cell wall beta-1,6-glucan levels in Saccharomyces cerevisiae. [D] . Dijkgraaf, Gerrit Jan Peter. 2002

机译：酿酒酵母中正常的细胞壁β-1,6-葡聚糖水平需要N链葡萄糖加工和适当的β-1,3-葡聚糖生物合成。
6. Highly Efficient Chemoenzymatic Synthesis of β1–4-Linked Galactosides with Promiscuous Bacterial β1–4-Galactosyltransferases [O] . Kam Lau, Vireak Thon, Hai Yu, -1

机译：β1-4联半乳糖苷的高效化学酶法合成混杂细菌β1-4半乳糖
7. Synthesis of β-1,4-Linked Galactan Side-Chains of Rhamnogalacturonan I [O] . Andersen Mathias Christian Franch, Kracun Stjepan, Rydahl Maja, 2016

机译：鼠李糖半乳糖醛酸β-1,4-连接的半乳糖侧链的合成

Synthesis of beta-1,4-Linked Galactan Side-Chains of Rhamnogalacturonan I

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