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首页> 外文期刊>Current Biology: CB >Partitioning and Remodeling of the Schizosaccharomyces japonicus Mitotic Nucleus Require Chromosome Tethers
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Partitioning and Remodeling of the Schizosaccharomyces japonicus Mitotic Nucleus Require Chromosome Tethers

机译：日本裂殖酵母有丝分裂核的分区和重塑需要染色体系链。

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During cellular proliferation, the mother nucleus divides into two daughters, each carrying a full complement of chromosomes and capable of driving the next cell cycle. Mitotic chromosome segregation must be coordinated with remodeling of other nuclear components, including the nuclear envelope (NE) and the non-membrane-bound nucleolus. Here, we show that in the fission yeast Schizosaccharomyces japonicus, which breaks and reforms the NE during mitosis [1, 2], the evolutionary conserved LEM-domain protein Man1 promotes equal partitioning of the nuclear membrane, nucleolar remodeling, and efficient inheritance of the nuclear pore complexes (NPCs) by the daughter nuclei. Analyses of man I mutants and results obtained using an artificial chromatin-nuclear pore tether suggest that Man1 may exert its function by linking the NPCs to segregating chromatin. By integrating the partitioning of the nuclear membrane and nucleolar material with chromosome segregation, cells build two nearly identical copies of the original nucleus.
机译：在细胞增殖期间，母核分为两个子，每个子携带完整的染色体补体，并能够驱动下一个细胞周期。有丝分裂染色体的分离必须与其他核成分，包括核被膜（NE）和非膜结合核仁的重塑协调。在这里，我们表明，在裂殖酵母日本裂殖酵母中，它在有丝分裂过程中破坏并改造了NE [1，2]，进化保守的LEM结构域蛋白Man1促进了核膜的均匀分配，核仁重塑以及核糖体的有效遗传。子核的核孔复合物（NPC）。 Man I突变体的分析和使用人工染色质-核孔系带获得的结果表明，Man1可能通过将NPC与分离的染色质连接而发挥其功能。通过整合核膜和核仁物质的分配与染色体分离，细胞可以构建原始核的两个几乎相同的副本。

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