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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Long-term effects of early maternal separation and isolation stress on adulthood behaviour of female rats
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Long-term effects of early maternal separation and isolation stress on adulthood behaviour of female rats

机译：母体早期分离和隔离压力对雌性大鼠成年行为的长期影响

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The present study demonstrates the long-term effect of early maternal separation (EMS) and isolation stress on the adult emotionality behaviour of female rats. The maternal separation (MS) of rat pups constituted both separation and isolation from the littermates for three days from post-natal days 5-7 (stress hyporesponsive period, MS(SHRP)) and 16-18 (post-stress hyporesponsive period, MS(PSHRP); 6 h/day) respectively. SHRP is characterized by reduced capacity to secrete stress hormone under stressful situations, which is postulated to be essential for the normal development of hypothalamic-pituitary-adrenal axis. A control group consisted of rat pups never handled or separated from the mother. At postnatal day 61, the rats were exposed to a light/dark test, exploratory activity in a novel environment and passive avoidance test. Both control and MS(PSHRP) groups did not differ in the latency to enter into the dark compartment, number of transitions between light and dark compartments and total motor activities in the preferred dark chamber. However, MS(SHRP) rats exhibited increased activity in the dark chamber in the light/dark test. When exposed to a novel environment, MS(PSHRP) groups exhibited significant decrease in the freezing response when compared to both control and MS(SHRP) groups. Furthermore, following exposure to a passive avoidance test, both MS groups showed decreased latency to enter into the preferred chamber with reduced locomotor activity in the dark compartment, indicating stress-induced decreased attention as a consequence of EMS stress.
机译：本研究证明了早期母体分离（EMS）和隔离压力对雌性大鼠成年情绪行为的长期影响。大鼠幼崽的母体分离（MS）从出生后5-7天（应激反应低下期，MS（SHRP））和16-18（应激后反应迟缓期，MS）的三天内与同窝仔的分离和分离（PSHRP）;每天6小时）。 SHRP的特征是在压力情况下分泌压力激素的能力降低，这被认为对下丘脑-垂体-肾上腺轴的正常发育至关重要。对照组由从未与母体接触或与母体分离的幼鼠组成。出生后第61天，大鼠接受明/暗测试，在新环境中的探索活动和被动回避测试。对照组和MS（PSHRP）组在进入暗室的潜伏期，亮室和暗室之间的过渡次数以及首选暗室中的总运动活动方面没有差异。但是，MS（SHRP）大鼠在明/暗测试中在暗室中显示出增加的活动。当暴露于新环境中时，与对照组和MS（SHRP）组相比，MS（PSHRP）组的冰冻反应显着降低。此外，在接受被动回避测试后，两个MS组均显示出进入暗室的运动能力降低的进入首选腔室的潜伏期缩短，这表明由于EMS应激导致压力引起的注意力下降。

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