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Bioactive compounds and health-promoting capacity of some Caucasian endemic and rare medicinal plants.

机译：一些高加索地方性和稀有药用植物的生物活性化合物和促进健康的能力。

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摘要

Despite the growth of the synthetic medicine production, there is a growing demand for herbal remedies for the world market. At the same time, in the last decades there has been a sharp increase of anthropogenic influence on the flora; particularly some rare and endangered herbs are more and more collected from wild populations in many regions of the world, also in Caucasian region, for local demand and export. The Caucasus is one of the richest and most threatened mountainous reservoirs of plant and animal life on Earth. The aim of this work is to study the content and the composition of biologically active compounds (essential oils, carotenoids, polyphenols, alkaloids and dianthrone derivatives) and their antioxidant capacity, as well as the lipid peroxidation potential of different eco races of some Caucasian endemic, rare, endangered and valuable medicinal plants as thyme (Thymus transcaucasicus), St John's-wort (Hypericum eleonorae) and knapweed (Centaurea hajastana). The metabolite profiles of these herbs were analyzed by GC/MS and HPLC. Bioactive compounds were quantified and their health-promoting properties were analyzed in bioassays. It was shown that the content, composition, antioxidant activity and lipid peroxidation potential of studied biologically active compounds significantly depends on plant provenances (eco races). Such research can provide new important knowledge about the bioactive compounds and their pharmacological effects of the most promising ecotypes of selected Caucasian endemic and rare species. It can also make significant contribution in discovering new effective drugs.
机译：尽管合成药物产量增长，但世界市场对草药的需求仍在增长。同时，在过去的几十年中，人为因素对菌群的影响急剧增加。尤其是越来越多的珍稀濒危草药是从世界许多地区（也包括高加索地区）的野生种群中收集的，用于当地需求和出口。高加索地区是地球上动植物最丰富，最受威胁的山区之一。这项工作的目的是研究生物活性化合物（精油，类胡萝卜素，多酚，生物碱和双蒽酮衍生物）的含量和组成及其抗氧化能力，以及某些白种人地方生种的不同生态种的脂质过氧化潜力。 ，稀有，濒临灭绝和有价值的药用植物，如百里香（百里香（Thymus transcaucasicus）），圣约翰草（Hypericum eleonorae）和矢车菊（Centaurea hajastana）。通过GC / MS和HPLC分析了这些草药的代谢产物。对生物活性化合物进行定量，并在生物测定中分析其促进健康的特性。结果表明，所研究的生物活性化合物的含量，组成，抗氧化活性和脂质过氧化潜力极大地取决于植物的种源（生态小种）。此类研究可以提供有关选定的白种人特有物种和稀有物种最有前途的生态型的生物活性化合物及其药理作用的新的重要知识。它还可以为发现新的有效药物做出重大贡献。

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    《Acta Horticulturae》 |2012年第955期|共8页
  • 作者

    Manukyan A.;

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