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首页> 外文期刊>ACS applied materials & interfaces >Multifunctional Redox-Responsive Mesoporous Silica Nanoparticles for Efficient Targeting Drug Delivery and Magnetic Resonance Imaging
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Multifunctional Redox-Responsive Mesoporous Silica Nanoparticles for Efficient Targeting Drug Delivery and Magnetic Resonance Imaging

机译：多功能氧化还原反应介孔二氧化硅纳米粒子的有效靶向药物输送和磁共振成像。

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摘要

The convenient modification of mesoporous silica nanoparticles (MSN) can provide great opportunities for constructing a new generation of nanocarriers with multiple functions. In the current study, we fabricated a new multifunctional drug delivery system based on MSN capped by gadolinium based bovine serum albumin complex (BSA-Gd) and hyaluronic acid (HA) via reductive-cleavable disulfide bond. In this multifunctional nanoparticle (MSN-ss-GHA), BSA-Gd component was prepared by biomineralization and acted as both smart gatekeeper and contrast agent for magnetic resonance (MR) imaging, while HA served as the targeted molecule to improve the specific affinity of MSN-ss-GHA toward cancer cells. The successful fabrication of MSN-ss-GHA was demonstrated by a series of physicochemical characterization. The redox-sensitive drug release behavior of doxorubicin hydrochloride (DOX) loaded MSN-ss-GHA (DOX@MSN-ss-GHA) was also verified. Comparatively, the MSN-ss-GHA exhibited excellent biocompatibility and distinctly enhanced cell uptake by 4T1 cells. More importantly, the improved in vitro MR imaging ability of MSN-ss-GHA over that of Gd-DTPA was also confirmed. The results also suggested that the DOX@MSN-ss-GHA could efficiently deliver DOX into 4T1 cells and showed enhanced cytotoxicity as compared to that of nontargeted nanocarrier. The in vivo experiment also demonstrated the negligible toxicity of MSN-ss-GHA and improved antitumor suppression of DOX@MSN-ss-GHA. Thus, this multifunctional MSN-based theranostic agent holds potential for efficient redox-responsive targeting drug delivery and MR imaging.
机译：介孔二氧化硅纳米粒子（MSN）的方便修饰可以为构建具有多种功能的新一代纳米载体提供很大的机会。在当前的研究中，我们基于还原性可裂解的二硫键，以by为基础的牛血清白蛋白复合物（BSA-Gd）和透明质酸（HA）封端的MSN，制造了一种新型的多功能药物递送系统。在该多功能纳米粒子（MSN-ss-GHA）中，BSA-Gd成分是通过生物矿化制备的，既可作为智能门将，又可作为磁共振（MR）成像的造影剂，而HA则可作为目标分子来提高BSA-Gd的特异性亲和力MSN-ss-GHA对癌细胞的作用。一系列理化特性证明了MSN-ss-GHA的成功制备。还验证了载有盐酸阿霉素（MSN-ss-GHA）（DOX @ MSN-ss-GHA）的氧化还原敏感性药物释放行为。相比之下，MSN-ss-GHA表现出出色的生物相容性，并明显增强了4T1细胞的细胞摄取。更重要的是，还证实了MSN-ss-GHA的体外MR成像能力优于Gd-DTPA。结果还表明，与非靶向纳米载体相比，DOX @ MSN-ss-GHA可以有效地将DOX递送至4T1细胞，并显示出增强的细胞毒性。体内实验还证明了MSN-ss-GHA的毒性可忽略不计，并且改善了DOX @ MSN-ss-GHA的抗肿瘤抑制作用。因此，这种基于MSN的多功能治疗剂具有潜在的高效氧化还原反应性靶向药物递送和MR成像的潜力。

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