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首页> 外文期刊>ACS applied materials & interfaces >Strontium-Substituted Submicrometer Bioactive Glasses Modulate Macrophage Responses for Improved Bone Regeneration
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Strontium-Substituted Submicrometer Bioactive Glasses Modulate Macrophage Responses for Improved Bone Regeneration

机译：锶替代的亚微米生物活性玻璃调节巨噬细胞反应以改善骨再生

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摘要

Host immune response induced by foreign bone biomaterials plays an important role in determining their fate after implantation. Hence, it is well worth designing advanced bone substitute materials with beneficial immunomodulatory properties to modulate the host-material interactions. Bioactive glasses (BG), with excellent osteoconductivity and osteoinductivity, are regarded as important biomaterials in the field of bone regeneration. In order to explore a novel BG-based osteoimmunomodulatory implant with the capacity of potentially enhancing bone regeneration, it is a possible way to regulate the local immune microenvironment through manipulating macrophage polarization. In this study, strontium-substituted submicrometer bioactive glass (Sr-SBG) was prepared as an osteoimmunomodulatory bone repair material. To investigate whether the incorporation of Sr into SBG could synergistically improve osteogenesis by altering macrophage response, we systematically evaluated the interaction between Sr-SBG and macrophage during the process of bone regeneration by in vitro biological evaluation and in vivo histological assessment. It was found that the Sr-SBG modulates proper inflammatory status, leading to enhanced osteogenesis of mouse mesenchymal stem cells (mMSCs) and suppressed osteoclastogenesis of RAW 264.7 cells compared to SBG without strontium substitution. In vivo study confirmed that Sr-SBG initiated a less severe immune response and had an improved effect on bone regeneration than SBG, which corresponded with the in vitro evaluation. In conclusion, these findings suggested that Sr-SBG could be a promising immunomodulatory bone repair material designed for improved bone regeneration.
机译：外来骨生物材料诱导的宿主免疫反应在决定植入后的命运方面起着重要作用。因此，非常值得设计具有有益免疫调节特性的先进的骨替代材料，以调节宿主材料之间的相互作用。具有出色的骨传导性和骨诱导性的生物活性玻璃（BG）被认为是骨再生领域中的重要生物材料。为了探索具有潜在增强骨骼再生能力的新型基于BG的骨免疫调节植入物，这是一种通过操纵巨噬细胞极化来调节局部免疫微环境的可能方法。在这项研究中，制备了锶取代的亚微米生物活性玻璃（Sr-SBG）作为骨免疫调节性骨修复材料。为了研究将Sr掺入SBG是否可以通过改变巨噬细胞反应来协同改善成骨作用，我们通过体外生物学评估和体内组织学评估，系统评估了Sr-SBG与巨噬细胞在骨再生过程中的相互作用。发现与没有锶取代的SBG相比，Sr-SBG调节适当的炎症状态，从而导致小鼠间充质干细胞（mMSCs）的成骨作用增强，并抑制RAW 264.7细胞的破骨细胞生成。体内研究证实，与SBG相比，Sr-SBG引发的免疫应答较轻，并且对骨骼再生的效果更好。总之，这些发现表明，Sr-SBG可能是有前途的免疫调节性骨修复材料，旨在改善骨再生。

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