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首页> 外文期刊>ACS applied materials & interfaces >Diffusion of Fluorescently Labeled Bacteriocin from Edible Nanomaterials and Embedded Nano-Bioactive Coatings
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Diffusion of Fluorescently Labeled Bacteriocin from Edible Nanomaterials and Embedded Nano-Bioactive Coatings

机译：荧光标记的细菌素从食用纳米材料和嵌入式纳米生物活性涂层中的扩散。

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摘要

Application of nano-biotechnology to improve the controlled release of drugs or functional agents is widely anticipated to transform the biomedical, pharmaceutical, and food safety trends. The purpose of the current study was to assess and compare the release rates of fluorescently labeled antimicrobial peptide nisin (lantibiotic/biopreservative) from liposomal nanocarriers. The elevated temperature, high electrostatic attraction between anionic bilayers and cationic nisin, larger size, and higher encapsulation efficiency resulted in rapid and elevated release through pore formation. However, acidic pH and optimal ethanol concentration in food simulating liquid (FSL) improved the stability and retention capacity of loaded drug. Thus, controlling various factors had provided partition coefficient K values from 0.23 to 8.78 indicating variation in nisin affinity toward encapsulating macromolecule or FSL. Interaction between nisin and nanoscale bilayer systems by atomic force (AFM) and transmission electron microscopy demonstrated membrane activity of nisin from adsorption and aggregation to pore formation. Novel nanoactive films with preloaded nanoliposomes embedded in biodegradable polymer revealed improved morphological, topographic, and roughness parameters studied by confocal microscopy and AFM. Pre-encapsulated nanoactive biopolymer demonstrated excellent retention capacity as drug carriers by decreasing the partition coefficient value from 1.8 to 0.66 (similar to 30%) due to improved stability of nanoliposomes embedded in biopolymer network.
机译：广泛预期应用纳米生物技术改善药物或功能剂的控制释放，将改变生物医学，药物和食品安全趋势。本研究的目的是评估和比较荧光标记的抗菌肽乳链菌肽（羊毛硫抗生素/生物防腐剂）从脂质体纳米载体中的释放速率。高温，阴离子双层与阳离子乳链菌肽之间的高静电引力，较大的尺寸和较高的包封效率导致通过孔形成的快速且升高的释放。然而，食品模拟液（FSL）中的酸性pH和最佳乙醇浓度提高了所载药物的稳定性和保留能力。因此，控制各种因素已经提供了从0.23到8.78的分配系数K值，表明乳链菌肽亲和力对封装大分子或FSL的变化。乳链菌肽和纳米级双层系统之间的相互作用通过原子力（AFM）和透射电子显微镜证实，乳链菌肽的膜活性从吸附，聚集到孔形成。通过共聚焦显微镜和原子力显微镜研究，将预载纳米脂质体嵌入可生物降解的聚合物中的新型纳米活性薄膜显示出改善的形态学，形貌和粗糙度参数。预包封的纳米活性生物聚合物由于将嵌入生物聚合物网络的纳米脂质体的稳定性提高，通过将分配系数值从1.8降低至0.66（约30％），表现出优异的药物载体保留能力。

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