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首页> 外文期刊>ACS applied materials & interfaces >Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes
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Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes

机译：环糊精/阳离子三聚表面活性剂复合物的自聚集，抗菌活性和温和性

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Despite efficacious antimicrobial activity, cationic oligomeric surfactants show strong skin irritation potential due to their larger cationic charge numbers and multiple hydrophobic chains. This work reports that the incorporation of alpha-, beta-, and gamma-CDs with different cavity sizes can effectively improve the mildness of cationic ammonium trimeric surfactant DTAD with a star-shaped spacer while maintaining its high antibacterial activity. On the basis of the different cavity sizes of CDs and the asymmetry in the spacer of DTAD, the CD/DTAD mixtures form alpha-CD@DTAD, 2 alpha-CD@DTAD, beta-CD@DTAD, and gamma-CD@DTAD complexes. Compared to DTAD, these CD/DTAD complexes show much stronger self-assembly ability with much lower critical aggregation concentrations (CAC) and form more diverse aggregates with reduced zeta potential. Just above their CACs, the CD/DTAD complexes form vesicles or solid spherical aggregates of similar to 50 nm and then transform into small micelles of similar to 10 nm as the concentration increases. The strong self-assembly ability and the multiple sites of hydrogen bonds of the CD/DTAD complexes endow them with high antibacterial activity against E. coli, showing a very low minimum inhibitory concentration (2.22-2.48 mu M) comparable to that of DTAD. In particular, the addition of CDs significantly reduces the abilities of DTAD in solubilizing zein (a skin model protein) and in binding with zein, and the mildness decreases in the order of 2 alpha-CD@DTAD > beta-CD@DTAD > gamma-CD@DTAD > alpha-CD@DTAD. This tendency depends on their different self-assembling structures, and the formation of vesicles is approved to be in favor of the improvement of the mildness.
机译：尽管具有有效的抗菌活性，但由于阳离子低聚物表面活性剂具有较大的阳离子电荷数和多个疏水链，因此它们仍具有强烈的皮肤刺激潜力。这项工作报告说，合并具有不同腔尺寸的α-，β-和γ-CD可以有效地改善带有星形间隔基的阳离子铵三聚表面活性剂DTAD的温和性，同时保持其高抗菌活性。根据CD的不同腔尺寸和DTAD间隔物中的不对称性，CD / DTAD混合物形成alpha-CD @ DTAD，2个alpha-CD @ DTAD，β-CD@ DTAD和gamma-CD @ DTAD复合体。与DTAD相比，这些CD / DTAD复合物具有更强的自组装能力，临界聚集浓度（CAC）低得多，并形成了更多的聚集体，ζ电位降低了。 CD / DTAD复合物刚好位于其CAC上方，形成浓度约50 nm的囊泡或固体球形聚集体，然后随着浓度的增加转变成粒径约10 nm的小胶束。 CD / DTAD复合物强大的自组装能力和氢键的多个位点赋予它们对大肠杆菌的高抗菌活性，显示出与DTAD相当的最低抑菌浓度（2.22-2.48μM）。特别是，添加CD会显着降低DTAD增溶玉米蛋白（一种皮肤模型蛋白）以及与玉米蛋白结合的能力，并且其柔和度按2 alpha-CD @ DTAD> beta-CD @ DTAD> gamma的顺序降低-CD @ DTAD> alpha-CD @ DTAD。这种趋势取决于它们不同的自组装结构，并且囊泡的形成被认为有利于温和性的改善。

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