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首页> 外文期刊>American Journal of Physiology >Activation of intestinal smooth muscle cells by interstitial cells of Cajal in simulation studies.
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Activation of intestinal smooth muscle cells by interstitial cells of Cajal in simulation studies.

机译：在模拟研究中，Cajal的间质细胞激活了肠平滑肌细胞。

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Activation of a two-dimensional sheet network (5 parallel chains of 5 cells each) of simulated intestinal smooth muscle cells (SMCs) by one interstitial cell of Cajal (ICC) was modeled by PSpice simulation. The network of 25 cells was not interconnected by gap-junction channels; instead, excitation was transmitted by the electric field that develops in the junctional clefts (JC) when the prejunctional membrane fires an action potential (AP). Transverse propagation between the parallel chains occurs similarly. The ICC cell was connected to cell E5 of the network [5th cell of the 5th (E) chain] via a high-resistance junction. The stimulating current, applied to the ICC cell interior, was made to resemble the endogenous undershooting slow wave (I(SW)). An I(SW) of 2.4 nA (over a rise time of 4 ms) took the ICC cell from a resting potential (RP) of -80 mV to a membrane potential of -41 mV. The slow wave produced a large negative cleft potential in the JC (V(JC); ICC-E5). The V(jc) brought the postjunctional membrane of E5 to threshold, causing this cell to fire an AP. This, in turn, propagated throughout the SMC network. If the ICC cell was given an RP of -55 mV (like SMC) and a slow wave of 40 mV amplitude (I(SW) of 1.8 nA), it still activated the SMC network. This was also true when the ICC cell was made excitable (developing an overshooting, fast-rising AP). In summary, one ICC cell displaying a slow wave was capable of activating a network of SMC in the absence of gap junctions.
机译：通过PSpice模拟来模拟一个Cajal间质细胞（ICC）激活的模拟肠平滑肌细胞（SMCs）的二维薄片网络（每个5个细胞的5条平行链）的二维薄片网络的激活。 25个单元的网络未通过间隙连接通道互连;取而代之的是，当结膜触发动作电位（AP）时，通过在交界裂口（JC）中产生的电场传输激发。平行链之间的横向传播类似地发生。 ICC单元通过高电阻结连接到网络的单元E5 [第五条（E）链的第五个单元]。施加到ICC电池内部的刺激电流类似于内源性下冲慢波（I（SW））。 I（SW）为2.4 nA（在4 ms的上升时间内）使ICC电池从-80 mV的静息电位（RP）升至-41 mV的膜电位。慢波在JC（V（JC）; ICC-E5）中产生了很大的负裂隙电位。 V（jc）使E5的结后膜达到阈值，从而导致该单元触发AP。这又在整个SMC网络中传播。如果为ICC电池提供RP -55 mV（类似于SMC）和40 mV振幅的慢波（I（SW）为1.8 nA），它仍会激活SMC网络。当使ICC电池兴奋时（开发超调，快速上升的AP），情况也是如此。总之，在没有间隙连接的情况下，一个显示慢波的ICC电池能够激活SMC网络。

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