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首页> 外文期刊>American Journal of Physiology >Amylin receptor blockade stimulates food intake in rats.
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Amylin receptor blockade stimulates food intake in rats.

机译：胰岛淀粉样多肽受体阻滞刺激大鼠进食。

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Amylin is postulated to act as a hormonal signal from the pancreas to the brain to inhibit food intake and regulate energy reserves. Amylin potently reduces food intake, body weight, and adiposity when administered systemically or into the brain. Whether selective blockade of endogenous amylin action increases food intake and adiposity remains to be clearly established. In the present study, the amylin receptor antagonist acetyl-[Asn(30), Tyr(32)] sCT-(8-32) (AC187) was used to assess whether action of endogenous amylin is essential for normal satiation to occur. Non-food-deprived rats received a 3- to 4-h intravenous infusion of AC187 (60-2,000 pmol.kg(-1).min(-1)), either alone or coadministered with a 3-h intravenous infusion of amylin (2.5 or 5 pmol.kg(-1).min(-1)) or a 2-h intragastric infusion of an elemental liquid diet (4 kcal/h). Infusions began just before dark onset. Food intake and meal patterns during the first 4 h of the dark period were determined from continuous computer recordings of changes in food bowl weight. Amylin inhibited food intake by approximately 50%, and AC187 attenuated this response by approximately 50%. AC187 dose-dependently stimulated food intake (maximal increases from 76 to 171%), whether administered alone or with an intragastric infusion of liquid diet. Amylin reduced mean meal size and meal frequency, AC187 attenuated these responses, and AC187 administration alone increased mean meal size and meal frequency. These results support the hypothesis that endogenous amylin plays an essential role in reducing meal size and increasing the postmeal interval of satiety.
机译：胰岛淀粉样多肽被假定为从胰腺到大脑的激素信号，以抑制食物摄入并调节能量储备。当全身或脑内给药时，胰岛淀粉样多肽有效地减少食物摄入，体重和肥胖。是否选择性阻断内源性胰岛淀粉样多肽的作用是否会增加食物摄入和肥胖症尚待明确。在本研究中，使用胰岛淀粉样多肽受体拮抗剂乙酰基-[Asn（30），Tyr（32）] sCT-（8-32）（AC187）评估内源性胰岛淀粉样多肽的作用对于正常饱足发生是否必不可少。非食物匮乏的大鼠单独或与胰岛淀粉样变性蛋白3小时静脉内注射一起接受AC3-4的3至4小时静脉内输注（60-2,000 pmol.kg（-1）.min（-1）） （2.5或5 pmol.kg（-1）.min（-1））或2小时胃内输注基本流质饮食（4 kcal / h）。输液是在天黑之前开始的。从连续的计算机记录食物碗重量的变化来确定黑暗时段的前4小时内的食物摄入量和膳食模式。胰岛淀粉样多肽抑制食物摄入约50％，AC187减弱这种反应约50％。无论是单独使用还是与胃内流食一起饮食，AC187剂量依赖性地刺激食物摄入（最大增加了76％至171％）。胰岛淀粉样多肽减少平均进餐量和进餐频率，AC187减弱了这些反应，单独使用AC187可以增加平均进餐量和进餐频率。这些结果支持以下假设：内源性胰岛淀粉样多肽在减少进餐量和增加饱腹感的餐后间隔中起着至关重要的作用。

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