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首页> 外文期刊>American Journal of Physiology >A novel framework of circulatory equilibrium.
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A novel framework of circulatory equilibrium.

机译：循环平衡的新框架。

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A novel framework of circulatory equilibrium was developed by extending Guyton's original concept. In this framework, venous return (CO(V)) for a given stressed volume (V) was characterized by a flat surface as a function of right atrial pressure (P(RA)) and left atrial pressure (P(LA)) as follows: CO(V) = V/W - G(S)P(RA) - G(P)P(LA), where W, G(S), and G(P) denote linear parameters. In seven dogs under total heart bypass, CO(V), P(RA), P(LA), and V were varied to determine the three parameters in each animal with use of multivariate analysis. The coefficient of determination (r(2) = 0.92-0.99) indicated the flatness of the venous return surface. The averaged surface was CO(V) = V/0.129 - 19.61P(RA) - 3.49P(LA). To examine the invariability of the surface parameters among animals, we predicted the circulatory equilibrium in response to changes in stressed volume in another 12 dogs under normal and heart failure conditions. This was achieved by equating the standard surface with the individually measured cardiac output (CO) curve. In this way, we could predict CO [y = 0.90x + 5.6, r(2) = 0.95, standard error of the estimate (SEE) = 8.7 ml.min(-1).kg(-1)], P(RA) (y = 0.96x, r(2) = 0.98, SEE = 0.2 mmHg), and P(LA) (y = 0.89x + 0.5, r(2) = 0.98, SEE = 0.8 mmHg) reasonably well. We conclude that the venous return surface accurately represents the venous return properties of the systemic and pulmonary circulations. The characteristics of the venous return surface are invariable enough among animals, making it possible to predict circulatory equilibrium, even if those characteristics are unknown in individual animals.
机译：通过扩展盖顿的原始概念，开发了一种新的循环平衡框架。在此框架下，给定压力量（V）的静脉回流（CO（V））的特征是平坦表面是右心房压力（P（RA））和左心房压力（P（LA））的函数，如下：CO（V）= V / W-G（S）P（RA）-G（P）P（LA），其中W，G（S）和G（P）表示线性参数。在七只全心搭桥的狗中，使用多变量分析对CO（V），P（RA），P（LA）和V进行变化，以确定每只动物的三个参数。测定系数（r（2）= 0.92-0.99）表示静脉回流表面的平坦度。平均表面为CO（V）＝ V / 0.129-19.61P（RA）-3.49P（LA）。为了检查动物之间的表面参数的不变性，我们预测了在正常和心力衰竭条件下，循环的平衡是对另外12只狗的应激量变化的响应。这是通过将标准表面与单独测量的心输出量（CO）曲线等价来实现的。这样，我们可以预测CO [y = 0.90x + 5.6，r（2）= 0.95，估计的标准误差（SEE）= 8.7 ml.min（-1）.kg（-1）]，P（ RA）（y = 0.96x，r（2）= 0.98，SEE = 0.2 mmHg）和P（LA）（y = 0.89x + 0.5，r（2）= 0.98，SEE = 0.8 mmHg）相当好。我们得出的结论是，静脉回流表面准确地代表了全身和肺循环的静脉回流特性。在动物之间，静脉回流表面的特征是足够不变的，因此即使个别动物不知道这些特征，也可以预测循环平衡。

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