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首页> 外文期刊>American Journal of Physiology >Roles of baroreflex and vestibulosympathetic reflex in controlling arterial blood pressure during gravitational stress in conscious rats.
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Roles of baroreflex and vestibulosympathetic reflex in controlling arterial blood pressure during gravitational stress in conscious rats.

机译：压力反射和前庭交感神经反射在自觉大鼠重力引力控制动脉血压中的作用。

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Gravity acts on the circulatory system to decrease arterial blood pressure (AP) by causing blood redistribution and reduced venous return. To evaluate roles of the baroreflex and vestibulosympathetic reflex (VSR) in maintaining AP during gravitational stress, we measured AP, heart rate (HR), and renal sympathetic nerve activity (RSNA) in four groups of conscious rats, which were either intact or had vestibular lesions (VL), sinoaortic denervation (SAD), or VL plus SAD (VL + SAD). The rats were exposed to 3 G in dorsoventral axis by centrifugation for 3 min. In rats in which neither reflex was functional (VL + SAD group), RSNA did not change, but the AP showed a significant decrease (-8 +/- 1 mmHg vs. baseline). In rats with a functional baroreflex, but no VSR (VL group), the AP did not change and there was a slight increase in RSNA (25 +/- 10% vs. baseline). In rats with a functional VSR, but no baroreflex (SAD group), marked increases in both AP and RSNA were observed (AP 31 +/- 6 mmHg and RSNA 87 +/-10% vs. baseline), showing that the VSR causes an increase in AP in response to gravitational stress; these marked increases were significantly attenuated by the baroreflex in the intact group (AP 9 +/- 2 mmHg and RSNA 38 +/- 7% vs. baseline). In conclusion, AP is controlled by the combination of the baroreflex and VSR. The VSR elicits a huge pressor response during gravitational stress, preventing hypotension due to blood redistribution. In intact rats, this AP increase is compensated by the baroreflex, resulting in only a slight increase in AP.
机译：重力作用于循环系统，通过引起血液重新分配和减少静脉回流来降低动脉血压（AP）。为了评估重力反射期间压力感受性反射和前庭交感神经反射（VSR）在维持AP中的作用，我们测量了四组完整或有意识的清醒大鼠的AP，心率（HR）和肾交感神经活动（RSNA）。前庭病变（VL），窦房神经去神经（SAD）或VL加SAD（VL + SAD）。通过离心将大鼠暴露于腹背轴3G。在无反射功能的大鼠（VL + SAD组）中，RSNA不变，但AP表现出明显的下降（相对于基线为-8 +/- 1 mmHg）。在具有功能性压力反射但无VSR的大鼠（VL组）中，AP不变且RSNA略有增加（相对于基线为25 +/- 10％）。在具有功能性VSR但无压力反射的大鼠（SAD组）中，观察到AP和RSNA均显着增加（相对于基线，AP 31 +/- 6 mmHg和RSNA 87 +/- 10％），表明VSR引起在重力作用下AP增加;完整组的压力反射显着减弱了这些明显的增加（相对于基线，AP 9 +/- 2 mmHg和RSNA 38 +/- 7％）。总之，AP受压力反射和VSR的组合控制。在重力压力下，VSR引起巨大的升压反应，从而防止由于血液重新分配引起的低血压。在完整的大鼠中，这种AP的增加被压力反射补偿，导致AP的轻微增加。

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