• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Regional blood volume and peripheral blood flow in postural tachycardia syndrome.
【24h】

Regional blood volume and peripheral blood flow in postural tachycardia syndrome.

机译：姿势性心动过速综合征的局部血容量和外周血流量。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Variants of postural tachycardia syndrome (POTS) are associated with increased ["high-flow" POTS (HFP)], decreased ["low-flow" POTS (LFP)], and normal ["normal-flow" POTS (NFP)] blood flow measured in the lower extremities while subjects were in the supine position. We propose that postural tachycardia is related to thoracic hypovolemia during orthostasis but that the patterns of peripheral blood flow relate to different mechanisms for thoracic hypovolemia. We studied 37 POTS patients aged 14-21 yr: 14 LFP, 15 NFP, and 8 HFP patients and 12 healthy control subjects. Peripheral blood flow was measured in the supine position by venous occlusion strain-gauge plethysmography of the forearm and calf to subgroup patients. Using indocyanine green techniques, we showed decreased cardiac index (CI) and increased total peripheral resistance (TPR) in LFP, increased CI and decreased TPR in HFP, and unchanged CI and TPR in NFP while subjects were supine compared with control subjects. Blood volume tended to be decreased in LFP compared with control subjects. We used impedance plethysmography to assess regional blood volume redistribution during upright tilt. Thoracic blood volume decreased, whereas splanchnic, pelvic, and leg blood volumes increased, for all subjects during orthostasis but were markedly lower than control for all POTS groups. Splanchnic volume was increased in NFP and LFP. Pelvic blood volume was increased in HFP only. Calf volume was increased above control in HFP and LFP. The results support the hypothesis of (at least) three pathophysiologic variants of POTS distinguished by peripheral blood flow related to characteristic changes in regional circulations. The data demonstrate enhanced thoracic hypovolemia during upright tilt and confirm that POTS is related to inadequate cardiac venous return during orthostasis.
机译：姿势性心动过速综合征（POTS）的变异与[[高流量] POTS（HFP）]增加，[[低流量] POTS（LFP）]和正常[[正常流量] POTS（NFP）]相关。受试者仰卧时在下肢测量的血流量。我们提出姿势性心动过速与矫正过程中的胸廓血容量减少有关，但外周血流的模式与胸廓血容量减少的不同机制有关。我们研究了37位14-21岁的POTS患者：14位LFP，15位NFP和8位HFP患者以及12位健康对照组。通过亚组患者前臂和小腿的静脉阻塞应变仪体积描记法测量仰卧位的外周血流量。使用吲哚菁绿技术，与对照组相比，当我们仰卧时，LFP​​的心脏指数（CI）降低，总外周阻力（TPR）升高，HFP的CI增加，TPR降低，NFP的CI和TPR不变。与对照组相比，LFP的血容量趋于减少。我们使用阻抗体积描记法评估直立倾斜过程中局部血容量的重新分布。矫正期间所有受试者的胸腔血量减少，而内脏，骨盆和腿部血量增加，但所有POTS组的胸腔血量明显低于对照组。 NFP和LFP中内脏体积增加。仅HFP增加盆腔血量。小牛的体积增加到高于HFP和LFP的控制水平。结果支持（至少）POTS的三种病理生理变异的假说，该变异以与区域循环的特征性变化有关的外周血流为特征。数据表明直立倾斜过程中胸廓血容量增加，并证实POTS与矫正过程中心脏静脉回流不足有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号