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首页> 外文期刊>American Journal of Physiology >Plasma ATP during exercise: possible role in regulation of coronary blood flow.
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Plasma ATP during exercise: possible role in regulation of coronary blood flow.

机译：运动过程中的血浆ATP：可能在调节冠状动脉血流中发挥作用。

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摘要

It was previously shown that red blood cells release ATP when blood oxygen tension decreases. ATP acts on microvascular endothelial cells to produce a retrograde conducted vasodilation (presumably via gap junctions) to the upstream arteriole. These observations form the basis for an ATP hypothesis of local metabolic control of coronary blood flow due to vasodilation in microvascular units where myocardial oxygen extraction is high. Dogs (n = 10) were instrumented with catheters in the aorta and coronary sinus, and a flow transducer was placed around the circumflex coronary artery. Arterial and coronary venous plasma ATP concentrations were measured at rest and during three levels of treadmill exercise by using a luciferin-luciferase assay. During exercise, myocardial oxygen consumption increased approximately 3.2-fold, coronary blood flow increased approximately 2.7-fold, and coronary venous oxygen tension decreased from 19 to 12.9 mmHg. Coronary venous plasma ATP concentration increased significantly from 31.1 to 51.2 nM (P < 0.01) during exercise. Coronary blood flow increased linearly with coronary venous ATP concentration (P < 0.01). Coronary venous-arterial plasma ATP concentration difference increased significantly during exercise (P < 0.05). The data support the hypothesis that ATP is one of the factors controlling coronary blood flow during exercise.
机译：先前显示，当血氧张力降低时，红细胞释放ATP。 ATP作用于微血管内皮细胞，以产生逆行的血管扩张作用（可能通过间隙连接）至上游小动脉。这些发现构成了ATP假设的基础，该假设是由于心肌氧提取量较高的微血管单位中的血管扩张引起的冠状动脉血流量的局部代谢控制。狗（n = 10）在主动脉和冠状窦中装有导管，并在回旋冠状动脉周围放置了流量传感器。使用萤光素-萤光素酶测定法在静止和跑步机运动的三个水平期间测量动脉和冠状静脉血浆ATP的浓度。在运动期间，心肌耗氧量增加了约3.2倍，冠状动脉血流量增加了约2.7倍，冠状静脉血氧张力从19毫米汞柱降低到了12.9毫米汞柱。运动期间，冠状静脉血浆ATP浓度从31.1 nM显着增加至51.2 nM（P <0.01）。冠状动脉血流量随冠状静脉ATP浓度线性增加（P <0.01）。运动过程中冠状静脉-动脉血浆ATP浓度差异显着增加（P <0.05）。数据支持以下假设：ATP是运动期间控制冠状动脉血流量的因素之一。

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