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首页> 外文期刊>American Journal of Physiology >Depressed cardiac myofilament function in human diabetes mellitus.
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Depressed cardiac myofilament function in human diabetes mellitus.

机译：人糖尿病中心脏肌丝功能降低。

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摘要

Diabetes mellitus is associated with a distinct cardiomyopathy. Whether cardiac myofilament function is altered in human diabetes mellitus is unknown. Myocardial biopsies were obtained from seven diabetic patients and five control, nondiabetic patients undergoing coronary artery bypass surgery. Myofilament function was assessed by determination of the developed force-Ca2+ concentration relation in skinned cardiac cells from flash-frozen human biopsies. Separate control experiments revealed that flash freezing of biopsy specimens did not affect myofilament function. All patients in the diabetes mellitus cohort were classified as Type 2 diabetes mellitus patients, and most showed signs of diastolic dysfunction. Diabetes mellitus was associated with depressed myofilament function, that is, decreased Ca2+ sensitivity (29%, P < 0.05 vs. control) and a trend toward reduction of maximum Ca2+-saturated force (29%, P = 0.08 vs. control). The slope of the force-Ca2+ concentration relation (Hill coefficient) was not affected by diabetes, however. We conclude that human diabetes mellitus is associated with decreased cardiac myofilament function. Depressed cardiac myofilament Ca2+ responsiveness may underlie the decreased ventricular function characteristic of human diabetic cardiomyopathy.
机译：糖尿病与明显的心肌病有关。在人类糖尿病中心脏肌丝功能是否改变尚不清楚。从七名糖尿病患者和五名接受冠状动脉搭桥手术的非糖尿病对照患者中进行了心肌活检。通过确定冻存的人类活组织检查在皮肤的心脏细胞中发达的力-Ca2 +浓度关系来评估肌丝功能。单独的对照实验表明，活检标本的速冻不影响肌丝功能。糖尿病队列中的所有患者均被归为2型糖尿病患者，并且大多数表现出舒张功能障碍的迹象。糖尿病与肌丝功能降低有关，即降低的Ca2 +敏感性（29％，与对照组相比，P <0.05）和最大Ca2 +饱和力降低的趋势（与对照组相比，29％，P = 0.08）。但是，力量与Ca2 +浓度的关系（希尔系数）的斜率不受糖尿病的影响。我们得出结论，人类糖尿病与心脏肌丝功能降低有关。心肌肌丝Ca2 +应答性降低可能是人类糖尿病性心肌病心室功能下降的原因。

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