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首页> 外文期刊>American Journal of Physiology >A ventricular-vascular coupling model in presence of aortic stenosis.
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A ventricular-vascular coupling model in presence of aortic stenosis.

机译：存在主动脉瓣狭窄的心室-血管耦合模型。

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In patients with aortic stenosis, the left ventricular afterload is determined by the degree of valvular obstruction and the systemic arterial system. We developed an explicit mathematical model formulated with a limited number of independent parameters that describes the interaction among the left ventricle, an aortic stenosis, and the arterial system. This ventricular-valvular-vascular (V(3)) model consists of the combination of the time-varying elastance model for the left ventricle, the instantaneous transvalvular pressure-flow relationship for the aortic valve, and the three-element windkessel representation of the vascular system. The objective of this study was to validate the V(3) model by using pressure-volume loop data obtained in six patients with severe aortic stenosis before and after aortic valve replacement. There was very good agreement between the estimated and the measured left ventricular and aortic pressure waveforms. The total relative error between estimated and measured pressureswas on average (standard deviation) 7.5% (SD 2.3) and the equation of the corresponding regression line was y = 0.99x - 2.36 with a coefficient of determination r(2) = 0.98. There was also very good agreement between estimated and measured stroke volumes (y = 1.03x + 2.2, r(2) = 0.96, SEE = 2.8 ml). Hence, this mathematical V(3) model can be used to describe the hemodynamic interaction among the left ventricle, the aortic valve, and the systemic arterial system.
机译：在主动脉瓣狭窄的患者中，左心室后负荷由瓣膜阻塞程度和全身动脉系统决定。我们开发了一个由有限数量的独立参数构成的显式数学模型，该模型描述了左心室，主动脉瓣狭窄和动脉系统之间的相互作用。该心室-瓣膜-血管（V（3））模型由左心室的时变弹性模型，主动脉瓣的瞬时跨瓣压力-流量关系以及三叉戟的三要素风帆表示的组合组成血管系统。这项研究的目的是通过使用六名患有严重主动脉瓣狭窄的患者在更换主动脉瓣前后的压力-容积环数据来验证V（3）模型。估计的左心室和主动脉压力波形与测量的波形之间有很好的一致性。估计压力与测量压力之间的总相对误差为平均值（标准偏差）7.5％（标准偏差为2.3），相应回归线的方程为y = 0.99x-2.36，确定系数r（2）= 0.98。在估计的和测量的卒中量之间也有很好的一致性（y = 1.03x + 2.2，r（2）= 0.96，SEE = 2.8 ml）。因此，该数学V（3）模型可用于描述左心室，主动脉瓣和全身动脉系统之间的血液动力学相互作用。

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