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首页> 外文期刊>American Journal of Physiology >Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats.
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Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats.

机译：觉醒和应激神经肽状态对自由运动大鼠尿动力学功能的影响。

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摘要

Corticotropin-releasing factor (CRF) is a neurotransmitter in Barrington's nucleus neurons. These neurons can coregulate parasympathetic tone to the bladder (to modulate micturition) and brain noradrenergic activity (to affect arousal). To identify the role of CRF in the regulation of micturition, the effects of CRF agonists and antagonists on urodynamics in the unanesthetized rat were characterized. Rats were implanted with bladder and intrathecal or intraperitoneal catheters under isoflurane anesthesia. Cystometry was performed in the unanesthetized, unrestrained state at least 24 h later. In some cases, cortical electroencephalographic activity (EEG) was recorded simultaneously to assess arousal state. During cystometry, the state of arousal often shifted between waking and sleeping and urodynamic function changed depending on the state. Micturition threshold, bladder capacity, and micturition volume were all increased during sleep. The CRF1/CRF2 receptor agonists CRF and urocortin 2 increased bladder capacity and micturition volume in awake but not in sleeping rats. Conversely, the CRF1 receptor antagonists antalarmin and NBI-30775 increased urinary frequency and decreased bladder capacity in awake rats. The present results demonstrate a profound effect of the state of arousal on urodynamic function and suggest that simultaneous monitoring of EEG and cystometry may provide a useful model for studying nocturnal enuresis and other urinary disorders. In addition, the results provide evidence for an inhibitory influence of CRF in the spinal pathway on micturition. Targeting the CRF system in the spinal cord may provide a novel approach for treating urinary disorders.
机译：促肾上腺皮质激素释放因子（CRF）是Barrington核神经元中的一种神经递质。这些神经元可以使副交感神经调和到膀胱（调节排尿）和大脑去甲肾上腺素能活动（影响唤醒）。为了确定CRF在排尿调节中的作用，表征了CRF激动剂和拮抗剂对未麻醉大鼠尿动力学的影响。在异氟烷麻醉下，将大鼠植入膀胱，鞘内或腹膜内导管。至少在24小时后，在未麻醉，不受约束的状态下进行膀胱测量。在某些情况下，同时记录皮层脑电图活动（EEG）以评估唤醒状态。在膀胱测压期间，唤醒的状态通常在清醒和睡眠之间转换，并且尿动力学功能根据状态而改变。睡眠期间排尿阈值，膀胱容量和排尿量均增加。 CRF1 / CRF2受体激动剂CRF和urocortin 2可在清醒的大鼠中增加膀胱容量和排尿量，但在睡眠的大鼠中则不会。相反，CRF1受体拮抗剂antalarmin和NBI-30775在清醒的大鼠中增加尿频并降低膀胱容量。目前的结果表明唤醒状态对尿动力学功能的深刻影响，并建议同时监测脑电图和膀胱测压术可能为研究夜间遗尿症和其他泌尿系统疾病提供有用的模型。另外，该结果提供了脊髓中CRF对排尿的抑制作用的证据。靶向脊髓中的CRF系统可提供一种治疗泌尿系统疾病的新颖方法。

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