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首页> 外文期刊>American Journal of Physiology >Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping.
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Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping.

机译：抽气期间小脑大鼠和高频反射活动的高频振荡的选择性损失。

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Respiratory motor outputs contain medium-(MFO) and high-frequency oscillations (HFO) that are much faster than the fundamental breathing rhythm. However, the associated changes in power spectral characteristics of the major respiratory outputs in unanesthetized animals during the transition from normal eupneic breathing to hypoxic gasping have not been well characterized. Experiments were performed on nine unanesthetized, chemo- and barodenervated, decerebrate adult rats, in which asphyxia elicited hyperpnea, followed by apnea and gasping. A gated fast Fourier transform (FFT) analysis and a novel time-frequency representation (TFR) analysis were developed and applied to whole phrenic and to medial branch hypoglossal nerve recordings. Our results revealed one MFO and one HFO peak in the phrenic output during eupnea, where HFO was prominent in the first two-thirds of the burst and MFO was prominent in the latter two-thirds of the burst. The hypoglossal activity contained broadband power distribution withseveral distinct peaks. During gasping, two high-amplitude MFO peaks were present in phrenic activity, and this state was characterized by a conspicuous loss in HFO power. Hypoglossal activity showed a significant reduction in power and a shift in its distribution toward lower frequencies during gasping. TFR analysis of phrenic activity revealed the increasing importance of an initial low-frequency "start-up" burst that grew in relative intensity as hypoxic conditions persisted. Significant changes in MFO and HFO rhythm generation during the transition from eupnea to gasping presumably reflect a reconfiguration of the respiratory network and/or alterations in signal processing by the circuitry associated with the two motor pools.
机译：呼吸运动输出包含中频（MFO）和高频振荡（HFO），它们比基本呼吸节律快得多。然而，在未麻醉动物从正常的向气性呼吸转变为低氧喘气的过程中，主要呼吸输出功率谱特征的相关变化尚未得到很好的表征。实验是对九只未麻醉，化学和经十二指肠切除的无脑成年大鼠进行的，其中窒息引起呼吸过度，然后出现呼吸暂停和喘气。门快速傅里叶变换（FFT）分析和新型的时频表示（TFR）分析已开发出来，并应用于整个and和内侧分支舌下神经的录音。我们的结果显示，在通气期间during气输出中有一个MFO和一个HFO峰值，其中HFO在爆发的前三分之二突出，而MFO在爆发的后三分之二突出。舌下活动包含宽带功率分布，具有多个不同的峰值。在喘气期间，在activity活动中存在两个高振幅MFO峰，这种状态的特征是HFO功率明显下降。舌下活动在喘气期间显示出功率的显着降低，并且其分布向低频移动。 TFR对en活动的分析表明，初始的低频“启动”爆发的重要性日益增加，随着缺氧情况的持续，这种爆发以相对的强度增长。从通气到喘气的过程中，MFO和HFO节奏产生的显着变化可能反映了呼吸网络的重新配置和/或与两个运动池相关的电路对信号处理的改变。

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