• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Activation of NADPH-diaphorase-positive projections to the rostral ventrolateral medulla following cardiac mechanoreceptor stimulation in the conscious rat.
【24h】

Activation of NADPH-diaphorase-positive projections to the rostral ventrolateral medulla following cardiac mechanoreceptor stimulation in the conscious rat.

机译：在有意识的大鼠中，在受到心脏机械感受器刺激后，NADPH-黄递酶阳性投射物向延髓腹侧延髓的激活。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Stimulation of cardiac mechanoreceptors during volume expansion elicits reflex compensatory changes in sympathetic nerve activity (SNA). The hypothalamic paraventricular nucleus (PVN) and nucleus of the tractus solitarius (NTS) are autonomic regions known to contribute to this reflex. Both of these nuclei project to the rostral ventrolateral medulla (RVLM), critical in the tonic generation of SNA. Recent reports from our laboratory show that these pathways 1) are activated following cardiac mechanoreceptor stimulation, and 2) produce nitric oxide, known to influence SNA. The aims of the present study were to determine whether 1) the activated neurons within the PVN and NTS were nitrergic and 2) these neurons projected to the RVLM. Animals were prepared, under general anesthesia, by microinjection of a retrogradely transported tracer into the pressor region of the RVLM and the placement of a balloon at the right venoatrial junction. In conscious rats, the balloon was inflated to stimulate the cardiac mechanoreceptors or was left uninflated. Balloon inflation elicited a significant increase in Fos-positive neurons in the parvocellular PVN (sevenfold) and NTS (fivefold). In the PVN, 51% of nitrergic neurons and 61% of RVLM-projecting nitrergic neurons were activated. In the NTS, these proportions were 8 and 18%, respectively. The data suggest that nitrergic neurons within the PVN and, to a lesser extent, in the NTS, some of which project to the RVLM, may contribute to the central pathways influencing SNA elicited by cardiac mechanoreceptor stimulation.
机译：体积扩大期间心脏机械感受器的刺激引起交感神经活动（SNA）的反射性补偿性变化。下丘脑室旁核（PVN）和孤束道核（NTS）是已知有助于这种反射的自主区域。这两个细胞核都投射到延髓性腹侧延髓（RVLM），这对SNA的补品产生至关重要。我们实验室的最新报告显示，这些途径1）在心脏机械感受器刺激后被激活，并且2）产生一氧化氮，已知会影响SNA。本研究的目的是确定1）PVN和NTS中激活的神经元是否为硝能，2）这些神经元是否投射到RVLM。在全麻下，通过将逆行运输的示踪剂显微注射到RVLM的加压区中，并在右室静脉连接处放置一个球囊来制备动物。在清醒的大鼠中，将球囊充气以刺激心脏机械感受器，或使其不充气。球囊膨胀引起小细胞PVN（七倍）和NTS（五倍）中Fos阳性神经元的显着增加。在PVN中，激活了51％的硝化神经元和61％的RVLM投射型硝化神经元。在NTS中，这些比例分别为8％和18％。数据表明，PVN内以及较小范围内的NTS（其中一些投射到RVLM）中的硝化神经元可能有助于影响心脏机械感受器刺激引起的SNA的中枢通路。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号