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首页> 外文期刊>American Journal of Physiology >The COX-2 pathway regulates growth of atrophied muscle via multiple mechanisms.
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The COX-2 pathway regulates growth of atrophied muscle via multiple mechanisms.

机译：COX-2途径通过多种机制调节萎缩肌肉的生长。

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Loss of muscle mass occurs with disease, injury, aging, and inactivity. Restoration of normal muscle mass depends on myofiber growth, the regulation of which is incompletely understood. Cyclooxygenase (COX)-2 is one of two isoforms of COX that catalyzes the synthesis of prostaglandins, paracrine hormones that regulate diverse physiological and pathophysiological processes. Previously, we demonstrated that the COX-2 pathway regulates early stages of myofiber growth during muscle regeneration. However, whether the COX-2 pathway plays a common role in adult myofiber growth or functions specifically during muscle regeneration is unknown. Therefore, we examined the role of COX-2 during myofiber growth following atrophy in mice. Muscle atrophy was induced by hindlimb suspension (HS) for 2 wk, followed by a reloading period, during which mice were treated with either the COX-2-selective inhibitor SC-236 (6 mg x kg(-1) x day(-1)) or vehicle. COX-2 protein was expressed and SC-236 attenuated myofiber growth during reloading in both soleus and plantaris muscles. Attenuated myofiber growth in the soleus was associated with both decreased myonuclear addition and decreased inflammation, whereas neither of these processes mediated the effects of SC-236 on plantaris growth. In addition, COX-2(-/-) satellite cells exhibited impaired activation/proliferation in vitro, suggesting direct regulation of muscle cell activity by COX-2. Together, these data suggest that the COX-2 pathway plays a common regulatory role during various types of muscle growth via multiple mechanisms.
机译：肌肉质量的丧失会因疾病，受伤，衰老和不活动而发生。正常肌肉质量的恢复取决于肌纤维的生长，其调节尚不完全清楚。环氧合酶（COX）-2是COX的两种同工型之一，可催化前列腺素（调节各种生理和病理生理过程的旁分泌激素）的合成。以前，我们证明了COX-2途径可调节肌肉再生过程中肌纤维生长的早期阶段。但是，COX-2途径在成年肌纤维生长中起共同作用还是在肌肉再生过程中发挥特定作用尚不清楚。因此，我们检查了小鼠萎缩后肌纤维生长过程中COX-2的作用。后肢悬吊（HS）引起肌肉萎缩2周，然后再加载，在此期间用COX-2选择性抑制剂SC-236（6 mg x kg（-1）x天（- 1））或车辆。在比目鱼肌和plant肌的重装过程中，COX-2蛋白被表达，SC-236减弱了肌纤维的生长。比目鱼肌纤维生长减弱与肌核减少和炎症减少有关，而这些过程均未介导SC-236对plant生长的影响。此外，COX-2（-/-）卫星细胞在体外表现出受损的激活/增殖，表明COX-2对肌肉细胞活性的直接调节。总之，这些数据表明，COX-2途径通过多种机制在各种类型的肌肉生长过程中起着共同的调节作用。

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