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首页> 外文期刊>American Journal of Physiology >Hypothalamic paraventricular nucleus, but not vasopressin, participates in chronic hyperactivity of the HPA axis in diabetic rats.
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Hypothalamic paraventricular nucleus, but not vasopressin, participates in chronic hyperactivity of the HPA axis in diabetic rats.

机译：下丘脑室旁核但不是加压素参与糖尿病大鼠中HPA轴的慢性活动亢进。

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摘要

Diabetes mellitus (DM), as chronic stress activates the hypothalamo-pituitary-adrenocortical axis. We examined whether arginine vasopressin (AVP) and the hypothalamic paraventricular nucleus (PVN) participate in DM-induced chronic stress symptoms. AVP-deficient Brattleboro or PVN-lesioned Wistar rats were used with heterozygous or sham-operated controls. The rats were studied 2 wk after a single injection of streptozotocin. The appearance of DM (enhanced water consumption and blood glucose elevation) and the chronic stress-like somatic changes (body weight decrease, thymus involution, adrenal gland hypertrophy) were not influenced by the lack of AVP. By contrast, PVN lesion significantly attenuated DM-induced thymus involution and adrenal gland hypertrophy as well as the increase in water consumption. The corticotropin-releasing hormone mRNA in PVN was diminished by DM and elevated by the lack of AVP without interaction. DM elevated the proopiomelanocortin (POMC) mRNA in the anterior lobe of the pituitary. The lack of AVP had no effect, whereas lesioning the PVN significantly diminished the elevation. The elevated basal corticosterone plasma levels detectable in DM were influenced neither by the lack of AVP nor by lesioning the PVN. Thus the lack of AVP had no influence on DM-induced chronic stress symptoms, but lesioning the PVN attenuated part of them. However, the lack of elevation in POMC mRNA after PVN lesion, together with the maintained corticosterone elevation, suggests that direct adrenal gland activation occurs in untreated DM.
机译：糖尿病（DM），因为慢性应激会激活下丘脑-垂体-肾上腺皮质轴。我们检查了精氨酸加压素（AVP）和下丘脑室室旁核（PVN）是否参与DM引起的慢性应激症状。 AVP缺陷的Brattleboro或PVN损伤的Wistar大鼠与杂合或假手术对照组一起使用。单次注射链脲佐菌素后2周对大鼠进行研究。 DM的出现（增强的水消耗和血糖升高）和慢性应激样体细胞变化（体重减轻，胸腺退化，肾上腺肥大）不受AVP的影响。相比之下，PVN病变显着减轻了DM引起的胸腺退化和肾上腺肥大以及水消耗的增加。 DM可减少PVN中促肾上腺皮质激素释放激素mRNA的表达，并因缺乏AVP而无相互作用而使之升高。 DM升高垂体前叶的proopiomelanocortin（POMC）mRNA。缺乏AVP无效，而损伤PVN则明显降低了海拔。在DM中可检测到的升高的基础皮质酮血浆水平既不受缺乏AVP的影响，也不受PVN的损害的影响。因此，缺乏AVP对DM引起的慢性应激症状没有影响，但损伤PVN会减轻部分症状。然而，PVN损伤后POMC mRNA缺乏升高，以及皮质酮维持升高，提示未经治疗的DM发生直接的肾上腺激活。

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