• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.
【24h】

Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.

机译：实验性结肠炎中乳香酸衍生物抗炎作用的潜在机制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent clinical trials of the gum resin of Boswellia serrata have shown promising results in patients with ulcerative colitis. The objective of this study was to determine whether a semisynthetic form of acetyl-11-keto-beta-boswellic acid (sAKBA), the most potent anti-inflammatory component of the resin, also confers protection in experimental murine colitis induced by dextran sodium sulfate (DSS) to compare its effects with those standard medications of ulcerative colitis like steroids and to examine whether leukocyte-endothelial cell adhesion is a major target of action of sAKBA. Clinical measurements of disease activity and histology were used to assess disease progression, and intravital microscopy was employed to monitor the adhesion of leukocytes and platelets in postcapillary venules of the inflamed colon. sAKBA treatment significantly blunted disease activity as assessed both grossly and by histology. Similarly, the recruitment of adherent leukocytes and platelets into inflamed colonic venules was profoundly reduced in mice treated with sAKBA. Because previous studies in the DSS model have shown that P-selectin mediates these blood cell-endothelial cell interactions, the expression of P-selectin in the colonic microcirculation was monitored using the dual-radiolabeled antibody technique. The treatment of established colitis with sAKBA largely prevented the P-selectin upregulation normally associated with DSS colitis. All of the protective responses observed with sAKBA were comparable to that realized in mice treated with a corticosteroid. Our findings demonstrated an anti-inflammatory effect of sAKBA and indicated that P-selectin-mediated recruitment of inflammatory cells is a major site of action for this novel anti-inflammatory agent.
机译：乳香乳香树胶树脂的最新临床试验显示，溃疡性结肠炎患者的结果令人鼓舞。这项研究的目的是确定半合成形式的乙酰基-11-酮-β-乳香酸（sAKBA）（该树脂最有效的消炎成分）是否也能赋予葡聚糖硫酸钠诱发的实验性小鼠结肠炎以保护作用（DSS）来比较其与溃疡性结肠炎的标准药物（如类固醇）的作用，并检查白细胞-内皮细胞粘附是否是sAKBA作用的主要目标。使用疾病活动性和组织学的临床测量来评估疾病的进展，并使用活体显微镜检查来监测发炎结肠的毛细血管后小静脉中白细胞和血小板的粘附。总体上和组织学评估，sAKBA治疗显着减弱了疾病活动。同样，在用sAKBA处理的小鼠中，粘附白细胞和血小板募集到发炎的结肠小静脉中的比例大大降低。因为以前在DSS模型中的研究表明P-选择素介导了这些血细胞-内皮细胞的相互作用，所以使用双放射性标记的抗体技术监测了P-选择素在结肠微循环中的表达。用sAKBA治疗已确立的结肠炎可在很大程度上防止通常与DSS结肠炎相关的P-选择素上调。用sAKBA观察到的所有保护性反应都与用皮质类固醇治疗的小鼠相当。我们的发现证明了sAKBA的抗炎作用，并表明P-选择蛋白介导的炎症细胞募集是这种新型抗炎剂的主要作用部位。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号