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首页> 外文期刊>American Journal of Physiology >Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure.
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Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure.

机译：暴露于热中后，PVN中的脊突和神经能神经元被激活。

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The present study investigated the effect of acute thermal stimulation in conscious rats on the production of Fos, a marker of increased neuronal activity, in spinally projecting and nitrergic neurons in the hypothalamic paraventricular nucleus (PVN). The PVN contains a high concentration of nitrergic neurons, as well as neurons that project to the intermediolateral cell column (IML) of the spinal cord that can directly influence sympathetic nerve activity (SNA). During thermal stimulation, the PVN is activated, but it is unknown whether spinally projecting PVN neurons and the nitrergic neurons are involved. Compared with controls, rats exposed to an environmental temperature of 39 degrees C for 1 h had a 10-fold increase in the number of cells producing Fos in the PVN (133 +/- 23 vs. 1,336 +/- 43, respectively, P < 0.0001). Of the spinally projecting neurons in the PVN of heated rats (98 +/- 10), over 20% expressed Fos. Additionally, of the nitrergic neurons (NADPH-diaphorase positive) located in the parvocellular PVN (723 +/- 17), 40% also expressed Fos (P < 0.0001 compared with controls). Finally, there was a significant increase in the number of spinally projecting neurons in the PVN that were nitrergic and expressed Fos after heat exposure (12%) compared with controls (0.1%) (P < 0.0001). These results suggest that spinally projecting and nitrergic neurons in the PVN may contribute to the central pathways activated by thermal stimulation.
机译：本研究调查了有意识大鼠的急性热刺激对下丘脑室旁核（PVN）的脊柱投射神经和硝化神经元Fos（神经元活性增加的标志物）产生的影响。 PVN包含高浓度的硝化神经元，以及投射到脊髓的中间外侧细胞柱（IML）的神经元，这些神经元可直接影响交感神经活动（SNA）。在热刺激过程中，PVN被激活，但是尚不清楚是否牵涉到脊柱突出的PVN神经元和硝能神经元。与对照组相比，暴露于39摄氏度环境温度下1小时的大鼠在PVN中产生Fos的细胞数量增加了10倍（分别为133 +/- 23和1336 +/- 43，P <0.0001）。在受热大鼠的PVN（98 +/- 10）中，脊髓突出的神经元中有20％以上表达了Fos。此外，在细小细胞PVN（723 +/- 17）中的硝化神经元（NADPH-黄递酶阳性）中，40％的人也表达了Fos（与对照组相比，P <0.0001）。最后，与对照组（0.1％）相比，暴露于热后，PVN中呈硝化和表达Fos的脊髓突触神经元数量（12％）显着增加（P <0.0001）。这些结果表明，PVN中的脊髓投射神经和神经能神经元可能参与了热刺激激活的中枢通路。

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