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首页> 外文期刊>American Journal of Physiology >Knee ligament mechanical properties are not influenced by estrogen or its receptors.
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Knee ligament mechanical properties are not influenced by estrogen or its receptors.

机译：膝盖韧带的机械性能不受雌激素或其受体的影响。

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摘要

Women are at greater risk of tearing their knee anterior cruciate ligament (ACL) than men participating in similar athletic activities. There is currently no conclusive explanation for this disparity; however, as ACL injuries in women have been linked with estrogen fluctuations during the menstrual cycle, one hypothesis is that estrogen has a direct detrimental effect on knee ligament mechanical properties. This study investigated the influence of estrogen and its receptors (ER alpha and ER beta) on knee ligament mechanical properties. This was achieved by testing the viscoelastic and tensile mechanical properties of knee medial collateral ligaments (MCL) and ACLs from: 1) male Sprague-Dawley rats treated with either estrogen (17alpha-ethynylestradiol; 0.03 mg/kg) or an ER alpha-specific agonist (propyl pyrazole triol; 2 mg/kg), and 2) female mice with a null mutation of the gene encoding for ER beta. Estrogen treatment had no significant effects on the viscoelastic or tensile mechanical properties of the rat MCL or ACL. Similarly, pharmacological stimulation of ER alpha using a selective agonist in rats and genetic modulation of ER beta by null mutation of its gene in mice did not influence MCL or ACL properties. These data indicate that estrogen does not have a major direct effect on ligament mechanical properties. Energies for the prevention of the disproportionately high rate of knee ligament injuries in women may be better spent focusing on more established and modifiable risk factors, such as abnormalities in neuromuscular control about the knee.
机译：与参加类似体育活动的男性相比，女性撕裂膝盖前交叉韧带（ACL）的风险更大。对于这种差异，目前尚无定论。然而，由于女性的ACL损伤与月经周期中的雌激素波动有关，因此一个假设是雌激素对膝盖韧带的机械性能具有直接的有害影响。这项研究调查了雌激素及其受体（ERα和ERβ）对膝关节韧带力学性能的影响。这是通过测试以下方面的膝内侧副韧带（MCL）和ACL的粘弹性和拉伸力学性能来实现的：1）用雌激素（17α-乙炔雌二醇; 0.03 mg / kg）或ER alpha特异性治疗的雄性Sprague-Dawley大鼠受体激动剂（丙基吡唑三醇; 2 mg / kg），以及2）雌性小鼠，其编码ER beta的基因无效。雌激素处理对大鼠MCL或ACL的粘弹性或拉伸力学性能没有明显影响。同样，在大鼠中使用选择性激动剂进行药理学刺激ERα并通过小鼠基因无效突变对ERβ进行遗传调控，不会影响MCL或ACL特性。这些数据表明，雌激素对韧带的机械性能没有主要的直接影响。预防女性膝关节韧带损伤比例过高的方法可能更适合将精力集中在更加确定和可修改的危险因素上，例如膝盖神经肌肉控制异常。

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