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首页> 外文期刊>American Journal of Physiology >Glucocorticoids increase salt appetite by promoting water and sodium excretion.
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Glucocorticoids increase salt appetite by promoting water and sodium excretion.

机译：糖皮质激素通过促进水和钠的排泄增加食盐。

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Glucocorticoids [e.g., corticosterone and dexamethasone (Dex)], when administered systemically, greatly increase water drinking elicited by angiotensin and sodium ingestion in response to mineralocorticoids [e.g., aldosterone and deoxycorticosterone acetate (DOCA)], possibly by acting in the brain. In addition, glucocorticoids exert powerful renal actions that could influence water and sodium ingestion by promoting their excretion. To test this, we determined water and sodium intakes, excretions, and balances during injections of Dex and DOCA and their coadministration (DOCA+Dex) at doses commonly employed to stimulate ingestion of water and sodium. In animals having only water to drink, Dex treatment greatly increased water and sodium excretion without affecting water intake, thereby producing negative water and sodium balances. Similar results were observed when Dex was administered together with DOCA. In animals having water and saline solution (0.3 M NaCl) to drink, Dex treatment increased water and sodium excretion, had minimal effects on water and sodium intakes, and was associated with negative water and sodium balances. DOCA treatment progressively increased sodium ingestion, and both water and sodium intakes exceeded their urinary excretion, resulting in positive water and sodium balances. The combination of DOCA+Dex stimulated rapid, large increases in sodium ingestion and positive sodium balances. However, water excretion outpaced total fluid intake, resulting in large, negative water balances. Plasma volume increased during DOCA treatment and did not change during treatment with Dex or DOCA+Dex. We conclude that increased urinary excretion, especially of water, during glucocorticoid treatment may explain the increased ingestion of water and sodium that occurs during coadministration with mineralocorticoids.
机译：当全身给药时，糖皮质激素[例如皮质类固醇和地塞米松（Dex）]可极大地增加血管紧张素和钠摄入对盐皮质激素（例如醛固酮和乙酸脱氧皮质酮（DOCA））的反应而引起的饮水。此外，糖皮质激素发挥强大的肾脏作用，可能通过促进其排泄而影响水和钠的摄入。为了测试这一点，我们确定了在注射Dex和DOCA及其共同给药（DOCA + Dex）时，通常用于刺激水和钠摄入的剂量下的水和钠摄入量，排泄量和平衡。在只喝水的动物中，Dex处理可大大增加水和钠的排泄，而不会影响水的摄入量，从而产生负的水和钠平衡。当与DOCA一起使用Dex时，观察到相似的结果。在喝水和盐溶液（0.3 M NaCl）的动物中，Dex处理可增加水和钠的排泄，对水和钠的摄入量影响最小，并且水和钠平衡为负值。 DOCA治疗逐渐增加钠的摄入量，水和钠的摄入量均超过其尿液排泄，从而导致水和钠平衡达到正值。 DOCA + Dex的组合刺激了钠摄入的快速大量增加和钠平衡的增加。但是，水排泄量超过了液体的总摄入量，导致大量的负水平衡。在DOCA治疗期间血浆体积增加，而在用Dex或DOCA + Dex治疗期间血浆体积没有变化。我们得出的结论是，糖皮质激素治疗期间尿排泄量增加，特别是水的排泄量增加，这可以解释与盐皮质激素共同给药期间水和钠的摄入量增加。

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