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首页> 外文期刊>American Journal of Physiology >Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population.
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Genetic and environmental interrelations between measurements of thyroid function in a healthy Danish twin population.

机译：丹麦双胞胎健康人群甲状腺功能测定之间的遗传和环境相关性。

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Serum thyrotropin (TSH), free thyroxine (T4), and free triiodothyronine (T3) levels illustrate the thyroid function set point, but the interrelations between these have never been characterized in detail. The aim of this study was to examine the associations between TSH and thyroid hormone levels in healthy euthyroid twins and to determine the extent to which the same genes influence more than one of these biochemical traits; 1,380 healthy euthyroid Danish twins (284 monozygotic, 286 dizygotic, 120 opposite-sex twin pairs) were recruited. Genetic and environmental associations between thyroid function measurements were examined using quantitative genetic modeling. In bivariate genetic models, the phenotypic relation between two measurements was divided into genetic and environmental correlations. Free T4 and free T3 levels were positively correlated (r=0.32, P<0.0001). The genetic correlation between serum free T4 and free T3 levels was rg=0.25 (95% CI 0.14-0.35), suggesting that a set of common genes affect both phenotypes (pleiotropy). The correlation between the environmental effects was re=0.41 (0.32-0.50). From this we calculated that the proportion of the correlation between free T4 and free T3 levels mediated by common genetic factors was 48%. Only 7% of the genetic component of serum free T3 levels is shared with serum free T4. Serum TSH and thyroid hormone levels did not share any genetic influences. In conclusion, thyroid hormone levels are partly genetically correlated genes that affect free T4 levels and exert pleiotropic effects on free T3 levels, although most of the genetic variance for these measurements is trait specific.
机译：血清促甲状腺激素（TSH），游离甲状腺素（T4）和游离三碘甲状腺素（T3）的水平说明了甲状腺功能设定点，但从未详细描述它们之间的相互关系。这项研究的目的是检查健康正常甲状腺双胞胎中TSH与甲状腺激素水平之间的关联，并确定相同基因影响这些生化特征中的一种以上的程度。招募了1,380例健康的正常甲状腺丹麦双胞胎（284个单卵双卵，286个卵双卵双卵，120个异性双卵双卵）。使用定量遗传模型检查甲状腺功能测量之间的遗传和环境关联。在双变量遗传模型中，两次测量之间的表型关系被分为遗传和环境相关性。游离T4和游离T3水平呈正相关（r = 0.32，P <0.0001）。血清游离T4和游离T3水平之间的遗传相关性为rg = 0.25（95％CI 0.14-0.35），这表明一组共同的基因会影响这两种表型（多态性）。环境影响之间的相关性重新等于0.41（0.32-0.50）。据此，我们计算出由常见遗传因素介导的游离T4和游离T3水平之间的相关比例为48％。无血清T3水平的遗传成分中只有7％与无血清T4共有。血清TSH和甲状腺激素水平没有任何遗传影响。总之，甲状腺激素水平是部分与遗传相关的基因，会影响游离T4水平并对游离T3水平产生多效作用，尽管这些测量的大多数遗传变异是特异的。

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