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首页> 外文期刊>Contraception >Prospective study of weight change in new adolescent users of DMPA, NET-EN, COCs, nonusers and discontinuers of hormonal contraception.
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Prospective study of weight change in new adolescent users of DMPA, NET-EN, COCs, nonusers and discontinuers of hormonal contraception.

机译：DMPA，NET-EN，COC，未使用和激素避孕药的青少年使用者中体重变化的前瞻性研究。

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BACKGROUND: Weight gain is commonly reported as a side effect of hormonal contraception and can lead to method discontinuation or reluctance to initiate the method. The purpose of this study was to investigate weight change in adolescent (aged 15-19 years) users of depot-medroxyprogesterone acetate (DMPA), norethisterone enanthate (NET-EN), combined oral contraceptives (COCs) and discontinuers of these methods as compared to nonusers of hormonal contraception. STUDY DESIGN: This longitudinal study recruited initiators of DMPA (n=115), NET-EN (n=115), COCs (n=116) and nonusers of contraception (n=144). Participants were followed up for 4-5 years, and details of current contraceptive method, including switching, discontinuing and/or starting hormonal methods were documented at each 6-monthly visit. Women were classified according to their contraceptive histories on completion of the study, and injectable users were combined into one group for analysis. Height, weight and self-reported dieting were recorded at each visit. RESULTS: There was no difference in mean age or weight between the groups at baseline. Women using DMPA or NET-EN throughout, or switching between the two, had gained an average of 6.2 kg compared to average increases of 2.3 kg in the COC group, 2.8 kg in nonusers and 2.8 kg among discontinued users of any method (p=.02). There was no evidence of a difference in weight gain between women classified as nonobese or classified as overweight/obese in any of the four study groups at baseline. CONCLUSION: There is fairly strong evidence that adolescent contraceptive hormonal injectable users appear to gain more weight than COC users, discontinuers and nonusers of contraception.
机译：背景：体重增加通常被报告为激素避孕的副作用，可能导致方法中断或不愿意启动该方法。这项研究的目的是调查青少年（15-19岁）使用醋酸甲羟孕酮（DMPA），炔诺酮庚酸酯（NET-EN），联合口服避孕药（COCs）和停用这些方法的青少年的体重变化非激素使用者。研究设计：这项纵向研究招募了DMPA（n = 115），NET-EN（n = 115），COC（n = 116）和非避孕药使用者（n = 144）的发起者。对参与者进行了4-5年的随访，每6个月一次随访记录了当前避孕方法的详细信息，包括转换，停用和/或开始激素的方法。完成研究后，根据妇女的避孕史对妇女进行分类，并将可注射的使用者分为一组进行分析。每次访视时记录身高，体重和自我报告的节食。结果：基线时两组之间的平均年龄或体重没有差异。始终使用DMPA或NET-EN或在两者之间切换的女性平均增加了6.2千克，而COC组平均增加了2.3千克，非使用者平均增加了2.8千克，而任何方式停用的使用者中平均增加了2.8千克（p = .02）。在基线的四个研究组中，没有证据表明被分类为非肥胖或被分类为超重/肥胖的女性之间体重增加有所不同。结论：有相当有力的证据表明，青春期避孕药激素注射使用者的体重似乎比COC使用者，停药者和非避孕药使用者增加。

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