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首页> 外文期刊>American Journal of Physiology >Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol.
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Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol.

机译：预防白藜芦醇治疗的主动脉束缚大鼠同心肥大和舒张功能障碍。

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摘要

This study was designed to examine the effects of the antioxidant resveratrol on cardiac structure and function in pressure overload (PO)-induced cardiac hypertrophy. Male Sprague-Dawley rats were subjected to sham operation and the aortic banding procedure. A subgroup of sham control and aortic-banded rats were treated with resveratrol for 2 wk after surgery. Echocardiographic analysis of cardiac structure and function along with Western blot analysis of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and redox factor-1 (ref-1) were performed in all groups after 4 wk of surgery. Banded rats showed significantly increased left ventricle-to-body weight ratio. Echocardiographic analysis showed that the interventricular septal wall thickness and left ventricular posterior wall thickness at systole and diastole were significantly increased in banded rats. Also, a significant increase in isovolumic relaxation time was observed in banded rats. Measured eNOS, iNOS, and ref-1 protein levels were significantly reduced in banded rats. Resveratrol treatment prevented the above changes in cardiac structure, function, and protein expression in banded rats. Aortic banding after 4 wk resulted in concentric remodeling and impaired contractile function due to PO on the heart. The 2-wk treatment with resveratrol was found to abolish PO-induced cardiac hypertrophy. Resveratrol may therefore be beneficial against PO-induced cardiac hypertrophy found in clinical settings of hypertension and aortic valve stenosis.
机译：本研究旨在检查抗氧化剂白藜芦醇对压力超负荷（PO）引起的心肌肥大中心脏结构和功能的影响。对雄性Sprague-Dawley大鼠进行假手术和主动脉绑扎程序。假对照组和主动脉束缚大鼠的亚组在手术后用白藜芦醇治疗2周。在手术4周后，所有组均进行了超声心动图分析，包括心脏一氧化氮合酶（eNOS），诱导型一氧化氮合酶（iNOS）和氧化还原因子-1（ref-1）的蛋白质印迹分析。带状的大鼠显示左心室与体重的比率显着增加。超声心动图分析显示，束缚大鼠的室间隔和左室后壁厚度在收缩期和舒张期显着增加。另外，在带状大鼠中观察到等容舒张时间的显着增加。带状大鼠中测得的eNOS，iNOS和ref-1蛋白水平显着降低。白藜芦醇治疗阻止了带状大鼠心脏结构，功能和蛋白质表达的上述变化。 4周后主动脉束带导致同心重塑，并且由于心脏上的PO导致收缩功能受损。发现白藜芦醇的2周治疗可消除PO诱导的心脏肥大。因此，白藜芦醇可能对在高血压和主动脉瓣狭窄的临床环境中发现的PO诱发的心肌肥大有益。

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