in a 1991 review article titled "The pancreatic islet as Rubik's cube. Is phospholipid hydrolysis a piece of the puzzle?" (26), Stewart Metz concluded that "an obligate role for phospho-lipase activation in glucose-induced insulin secretion is not yet rigorously established, despite tantalizing, inferential evidence." This statement remained accurate for more than 15 years. Recent studies by Bao and colleagues (2, 5) and Jacobson et al. (13), including a recent article appearing in AJP-Endocrinology and Metabolism (2), provide key supportive evidence for a role of Group VTA phospholipase A2 (iPLA2beta) in insulin secretion.
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机译：在1991年的一篇评论文章中，标题为“胰岛就像魔方一样。磷脂水解是否是一个难题？” （26），斯图尔特·梅斯（Stewart Metz）得出结论：“尽管诱人的推论依据，但尚未严格确立磷酸脂酶激活在葡萄糖诱导的胰岛素分泌中的作用。”该声明在超过15年的时间内一直保持准确。 Bao及其同事（2，5）和Jacobson等人的最新研究。 （13），包括最近发表在AJP-Endocrinology and Metabolism（2）上的一篇文章，为VTA组磷脂酶A2（iPLA2beta）在胰岛素分泌中的作用提供了重要的支持证据。
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