Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the a-myosin heavy chain expression

Jyothish B. Pillai; Martin Chen; Senthilkumar B. Rajamohan; Sadhana Samant; Vinodkumar B. Pillai

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Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the a-myosin heavy chain expression

机译：SIRT1，III类组蛋白脱乙酰基酶的激活有助于果糖进料介导的α-肌球蛋白重链表达的诱导

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in response to sustained hemodynamic overload, the heart initially compensates with an adaptive hypertrophic growth of the myocardium. Under prolonged stress conditions, the heart eventually develops irreversible changes that result in ventricular dilation and heart failure. At the cellular level, stress-induced cardiac hypertrophy is associated with an increase of myocyte cell size and activation of fetal genes encoding proteins involved in contractility, Ca~(2+) transport, and cell energetics (reviewed in Ref. 16).

机译：为了响应持续的血流动力学超负荷，心脏最初会补偿心肌的适应性肥大生长。在长时间的压力条件下，心脏最终会发展成不可逆的变化，从而导致心室扩张和心力衰竭。在细胞水平上，应激诱导的心脏肥大与心肌细胞大小的增加和胎儿基因的激活有关，该基因编码涉及收缩性，Ca〜（2+）转运和细胞能量学的蛋白质（参见参考文献16）。

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《American Journal of Physiology》 |2008年第2期|共10页
作者
Jyothish B. Pillai; Martin Chen; Senthilkumar B. Rajamohan; Sadhana Samant; Vinodkumar B. Pillai;
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正文语种 eng
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Feeding; Stress; Myosins; Histone Deacetylase; Heart; 应激; 组蛋白脱乙酰基酶;

机译：Feeding;Stress;Myosins;Histone Deacetylase;Heart;应激;组蛋白脱乙酰基酶;

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1. Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the a-myosin heavy chain expression [J] . Jyothish B. Pillai, Martin Chen, Senthilkumar B. Rajamohan, American Journal of Physiology . 2008,第3aPta2期

机译：SIRT1，III类组蛋白脱乙酰基酶的激活有助于果糖进料介导的α-肌球蛋白重链表达的诱导
2. Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1 [J] . Lee Ju-Hee, Kim Jin-Shang, Park Sang-Youel, Oncology reports . 2016,第1期

机译：白藜芦醇通过激活III类组蛋白脱乙酰基酶Sirt1诱导人角质形成细胞损伤
3. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation [J] . Sinyi Kong, Seung-Jae Kim, Barry Sandal, The Journal of biological chemistry . 2011,第19期

机译：III型组蛋白脱乙酰酶SIRT1蛋白在BCLAF1启动子下抑制P300介导的组蛋白H3赖氨酸56乙酰化，以抑制T细胞活化
4. INHIBITION OF THE EXPRESSION OF IgE HEAVY CHAIN GERMLINE TRANSCRIPTS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ LIGANDS [C] . Yoshiyuki MIYAZAKI, Hirofumi TACHIBANA, Koji YAMADA Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

机译：过氧化物体增殖物激活受体-γ配体抑制IgE重链种系转录物的表达
5. Expression of HLA class I heavy chain and TcR gamma-chain homologs in human cytomegalovirus-infected human cells [D] . Mostello, Elizabeth Antonia 1998

机译：HLA I类重链和TcRγ链同源物在人巨细胞病毒感染的人细胞中的表达
6. Activation of Tripartite Motif Containing 63 Expression by Transcription Factor EB and Transcription Factor Binding to Immunoglobulin Heavy Chain Enhancer 3 Is Regulated by Protein Kinase D and Class IIa Histone Deacetylases [O] . Cristina Pablo Tortola, Britta Fielitz, Yi Li, 2020

机译：通过蛋白激酶D和IIA类组蛋白脱乙酰酶来调节含有转录因子EB和转录因子结合的三方蛋白表达和转录因子重结合的三方基质。
7. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation* [O] . Kong, Sinyi, Kim, Seung-Jae, Sandal, Barry, 2011

机译：III型组蛋白去乙酰化酶Sirt1蛋白抑制Bclaf1启动子上p300介导的组蛋白H3赖氨酸56乙酰化，从而抑制T细胞活化*
8. Regulation of 4F2 Heavy-Chain Gene Expression during Normal Human T-Cell Activation Can Be Mediated by Multiple Distinct Molecular Mechanisms [R] . Lindsten, T., June, C. H., Thompson, C. B., 1988

机译：正常人T细胞活化过程中4F2重链基因表达的调节可以通过多种不同的分子机制介导

Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the a-myosin heavy chain expression

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