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首页> 外文期刊>American Journal of Physiology >Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster.
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Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster.

机译：慢性乙醇会减弱昼夜节律性光相的复位并改变仓鼠的夜间活动模式。

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摘要

Acute ethanol (EtOH) administration impairs circadian clock phase resetting, suggesting a mode for the disruptive effect of alcohol abuse on human circadian rhythms. Here, we extend this research by characterizing the chronobiological effects of chronic alcohol consumption. First, daily profiles of EtOH were measured in the suprachiasmatic nucleus (SCN) and subcutaneously using microdialysis in hamsters drinking EtOH. In both cases, EtOH peaked near lights-off and declined throughout the dark-phase to low day-time levels. Drinking bouts preceded EtOH peaks by approximately 20 min. Second, hamsters chronically drinking EtOH received a light pulse during the late dark phase [Zeitgeber time (ZT) 18.5] to induce photic phase advances. Water controls had shifts of 1.2 +/- 0.2 h, whereas those drinking 10% and 20% EtOH had much reduced shifts (0.5 +/- 0.1 and 0.3 +/- 0.1 h, respectively; P < 0.001 vs. controls). Third, incremental decreases in light intensity (270 lux to 0.5 lux) were used to explore chronic EtOH effects on photic entrainment and rhythm stability. Activity onset was unaffected by 20% EtOH at all light intensities. Conversely, the 24-h pattern of activity bouts was disrupted by EtOH under all light intensities. Finally, replacement of chronic EtOH with water was used to examine withdrawal effects. Water controls had photic phase advances of 1.1 +/- 0.3 h, while hamsters deprived of EtOH for 2-3 days showed enhanced shifts (2.1 +/- 0.3 h; P < 0.05 vs. controls). Thus, in chronically drinking hamsters, brain EtOH levels are sufficient to inhibit photic phase resetting and disrupt circadian activity. Chronic EtOH did not impair photic entrainment; however, its replacement with water potentiated photic phase resetting.
机译：急性乙醇（EtOH）的给药会损害昼夜节律的相位重置，这提示了滥用酒精对人类昼夜节律的破坏作用的模式。在这里，我们通过表征慢性饮酒的时间生物学效应来扩展这项研究。首先，在裂口上核（SCN）中和皮下使用微透析法在喝EtOH的仓鼠中测量EtOH的每日概况。在这两种情况下，EtOH均在熄灯时达到峰值，并在整个黑暗阶段下降到白天的低水平。饮酒发作在EtOH高峰之前约20分钟。第二，长期喝EtOH的仓鼠在黑暗的后期[Zeitgeber时间（ZT）18.5]收到光脉冲，以诱导光相的发展。饮水对照组的变化为1.2 +/- 0.2 h，而饮用10％和20％EtOH的对照组的变化明显减少（分别为0.5 +/- 0.1和0.3 +/- 0.1 h;与对照组相比，P <0.001）。第三，光强度的逐渐降低（从270 lux到0.5 lux）被用于研究EtOH对光合剂和节律稳定性的慢性影响。在所有光照强度下，活性开始都不受20％EtOH的影响。相反，在所有光照强度下，EtOH均会破坏活动发作的24小时模式。最后，用水代替慢性EtOH可以检查戒断效果。水对照组的光合作用进展为1.1 +/- 0.3 h，而缺少EtOH 2-3天的仓鼠表现出增强的移位（2.1 +/- 0.3 h;与对照组相比，P <0.05）。因此，在长期饮酒的仓鼠中，脑中的EtOH水平足以抑制光合相的复位并破坏昼夜节律活动。慢性EtOH不会损害光合。然而，用水增强的光相复位代替它。

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