The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

Sukarieh R; Sonenberg N; Pelletier J

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The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

机译：eIF4E结合蛋白是热休克反应期间细胞质eIF4E重新定位的修饰剂。

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Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E.

机译：应激颗粒（SGs）是细胞应激的结果，包含停滞的翻译前起始复合物，并与环境侵害期间的细胞存活有关。 SG是动态实体，蛋白质在压力下会移入和移出它们。存在于SG中的蛋白质库中有真核起始因子4E（eIF4E），其是帽依赖性翻译所必需的翻译因子，其调节蛋白质合成的限速步骤。在本文中，我们证明了eIF4E定位到SG取决于一个阻遏蛋白家族，即eIF4E结合蛋白（4E-BPs）的存在。我们的结果表明4E-BPs调节eIF4E的SG定位。

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《American Journal of Physiology》 |2009年第2期|共11页
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Sukarieh R; Sonenberg N; Pelletier J;
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1. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. [J] . Sukarieh R, Sonenberg N, Pelletier J American Journal of Physiology . 2009,第5aPta2期

机译：EIF4E结合蛋白是在热休克反应期间细胞质EIF4E重复定量化的调节剂。
2. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. [J] . Sukarieh R, Sonenberg N, Pelletier J American Journal of Physiology . 2009,第5aPta2期

机译：eIF4E结合蛋白是热休克反应期间细胞质eIF4E重新定位的修饰剂。
3. Xhe eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response [J] . R. Sukarieh, N. Sonenberg, J. Pelletier American Journal of Physiology . 2009,第5aPta1期

机译：XHE EIF4E结合蛋白是在热休克反应期间细胞质EIF4E重复定量化的调节剂
4. Mining Heat Stress Induced Genes Encoding Heat Shock Proteins (HSPs) and Heat Stress Transcription Factors (HSFs) in Strawberry (Fragaria x ananassa) [C] . Lee-Fong Lin, Shih-Yi Liao, Jui-Hung Yen, International Conference on Mechanics and Control Engineering . 2014

机译：采矿热应激诱导在草莓（Fragaria x ananassa）中编码热休克蛋白（HSP）和热应激转录因子（HSF）的热应激诱导基因
5. The expression of heat shock protein 70, heat shock protein 90 and heat shock factor 1 within the bovine midcycle corpus luteum after stimulation with temperature in vitro and PGF2alpha in vitro and in vivo. [D] . Kopka, Melissa N. 2006

机译：热激蛋白70，热激蛋白90和热激因子1在体外温度和体外及体内PGF2α刺激后在牛黄体中体中的表达。
6. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response [O] . R. Sukarieh, N. Sonenberg, J. Pelletier -1

机译：eIF4E结合蛋白是热休克反应过程中胞质eIF4E重新定位的调节剂
7. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response [O] . Sukarieh, R., Sonenberg, N., Pelletier, J. 2009

机译：eIF4E结合蛋白是热休克反应过程中胞质eIF4E重新定位的调节剂

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

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