The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

Sukarieh R; Sonenberg N; Pelletier J

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The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

机译：EIF4E结合蛋白是在热休克反应期间细胞质EIF4E重复定量化的调节剂。

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Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eukaryotic initiation factor 4E (eIF4E), a translation factor required for cap-dependent translation and that regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate the SG localization of eIF4E.

机译：由于细胞应激导出的应激颗粒（SGS）含有被停滞的翻译后络合物，并且在环境损伤期间与细胞存活相关。 SGS是动态实体，蛋白质在压力期间搬入和退出。在SGS中存在的蛋白质的再胃部是真核引发因子4e（EIF4E），概述依赖性翻译所需的翻译因子，并调节蛋白质合成的速率限制步骤。在此，我们证明EIF4E至SGS的定位取决于阻遏蛋白的存在，EIF4E结合蛋白（4E-BPS）。我们的结果表明，4E-BPS调节EIF4E的SG定位。

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《American Journal of Physiology》 |2009年第2期|共11页
作者
Sukarieh R; Sonenberg N; Pelletier J;
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McGill University Montreal Quebec Canada H3G 1Y6.;

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正文语种 eng
中图分类人体生理学;
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1. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. [J] . Sukarieh R, Sonenberg N, Pelletier J American Journal of Physiology . 2009,第5aPta2期

机译：EIF4E结合蛋白是在热休克反应期间细胞质EIF4E重复定量化的调节剂。
2. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. [J] . Sukarieh R, Sonenberg N, Pelletier J American Journal of Physiology . 2009,第5aPta2期

机译：eIF4E结合蛋白是热休克反应期间细胞质eIF4E重新定位的修饰剂。
3. Xhe eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response [J] . R. Sukarieh, N. Sonenberg, J. Pelletier American Journal of Physiology . 2009,第5aPta1期

机译：XHE EIF4E结合蛋白是在热休克反应期间细胞质EIF4E重复定量化的调节剂
4. Mining Heat Stress Induced Genes Encoding Heat Shock Proteins (HSPs) and Heat Stress Transcription Factors (HSFs) in Strawberry (Fragaria x ananassa) [C] . Lee-Fong Lin, Shih-Yi Liao, Jui-Hung Yen, International Conference on Mechanics and Control Engineering . 2014

机译：采矿热应激诱导在草莓（Fragaria x ananassa）中编码热休克蛋白（HSP）和热应激转录因子（HSF）的热应激诱导基因
5. The expression of heat shock protein 70, heat shock protein 90 and heat shock factor 1 within the bovine midcycle corpus luteum after stimulation with temperature in vitro and PGF2alpha in vitro and in vivo. [D] . Kopka, Melissa N. 2006

机译：热激蛋白70，热激蛋白90和热激因子1在体外温度和体外及体内PGF2α刺激后在牛黄体中体中的表达。
6. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response [O] . R. Sukarieh, N. Sonenberg, J. Pelletier -1

机译：eIF4E结合蛋白是热休克反应过程中胞质eIF4E重新定位的调节剂
7. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response [O] . Sukarieh, R., Sonenberg, N., Pelletier, J. 2009

机译：eIF4E结合蛋白是热休克反应过程中胞质eIF4E重新定位的调节剂

The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response.

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