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首页> 外文期刊>American Journal of Physiology >Novel anti-adipogenic activity produced by human fibroblasts
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Novel anti-adipogenic activity produced by human fibroblasts

机译：人成纤维细胞产生的新型抗脂肪形成活性

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Fatty tissue is generally found in distinct "depots" distributed throughout the human body. Adipocytes from each of the various depots differ in their metabolic capacities and their responses to environmental stimuli. Although a general understanding of the factors responsible for adipogenic transformation has been achieved, much is not understood about the mechanisms of adipose tissue deposition and the phenotypes of the adipocytes found within each depot. A clue to the factors regulating fat deposition may come from studies of adipogenesis using primary human orbital fibroblasts from patients with thyroid eye disease, a condition in which intense inflammation leads to expansion of orbital adipose tissue via differentiation of fibroblasts to adipocytes. We have previously demonstrated that adipogenesis of orbital fibroblasts is negatively correlated with cellular expression of the Thy-1 surface marker. In this study, we developed a novel imaging flow cytometric approach for the assessment of adipogenesis to test the hypothetical dependence of adipogenic potential on lack of Thy-1 expression. Using this technique, we learned that Thy-1-positive fibroblasts are, in fact, capable of differentiating into adipocytes but are less likely to do so because they secrete a paracrine antiadipogenic factor. It is possible that such a factor plays an important role in the prevention of excess fat deposition in the normal orbit and may even be exploited as a therapy for the treatment of obesity, a major worldwide health concern.
机译：脂肪组织通常存在于分布于人体的不同“仓库”中。来自各个贮库的脂肪细胞的代谢能力和对环境刺激的反应各不相同。尽管已经对引起脂肪转化的因素有了一般的了解，但是对于脂肪组织沉积的机制和在每个贮库中发现的脂肪细胞的表型还没有多少了解。有关调节脂肪沉积的因素的线索可能来自使用甲状腺疾病患者的原代人眼眶成纤维细胞进行成脂的研究，在这种情况下，强烈的炎症会通过成纤维细胞分化为脂肪细胞而导致眼眶脂肪组织扩张。我们以前已经证明，眼眶成纤维细胞的脂肪生成与Thy-1表面标记的细胞表达呈负相关。在这项研究中，我们开发了一种新颖的成像流式细胞术方法来评估脂肪形成，以测试脂肪形成潜力对Thy-1表达缺乏的假设依赖性。使用这种技术，我们了解到，Thy-1阳性成纤维细胞实际上能够分化为脂肪细胞，但由于它们分泌旁分泌抗脂肪形成因子而因此不太可能分化为脂肪细胞。这种因素有可能在预防正常眼眶中过多的脂肪沉积中发挥重要作用，甚至有可能被用作治疗肥胖症的一种疗法，而肥胖症是全世界主要的健康问题。

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