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Role of clock genes in gastrointestinal motility

机译：时钟基因在胃肠动力中的作用

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摘要

Biological rhythms coordinate the timing of our internal bodily functions. Colonic motility follows a rhythm as well: most people will have a bowel movement in the morning and rarely during the night. Recent work provides a potential mechanism for this observation: the mouse colon possesses a functional circadian clock as well as a subset of rhythmically expressed genes that may directly impact on colonic motility. Furthermore, measures of colonic motility such as the colonic tissue contractile response to acetylcholine, stool output, and intracolonic pressure changes vary as a function of the time of day, but these variations are attenuated in mice with disrupted clock function. These laboratory findings are supported by clinical observations. Gastrointestinal symptoms such as diarrhea or constipation are prevalent among shift workers and time-zone travelers, both of which are conditions associated with disruptions in biological rhythms. This review will discuss new insights into the role of clock genes in colonic motility and their potential clinical relevance.
机译：生物节律协调我们内部身体机能的时间安排。结肠的运动也遵循节奏：大多数人在早晨排便，很少在晚上排便。最近的工作为这种观察提供了一种潜在的机制：小鼠结肠具有功能性的昼夜节律时钟以及有节奏地表达的基因的子集，这些基因可能直接影响结肠的运动。此外，结肠运动的量度，例如结肠组织对乙酰胆碱的收缩反应，粪便排出量和结肠内压力变化随一天中的时间而变化，但这些变化在时钟功能受到破坏的小鼠中减弱。这些实验室发现得到临床观察的支持。胃肠道症状如腹泻或便秘在轮班工人和时区旅行者中普遍存在，这两者都是与生物节律紊乱有关的疾病。这篇综述将讨论时钟基因在结肠运动中的作用及其潜在的临床意义的新见解。

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