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首页> 外文期刊>American Journal of Physiology >Splanchnic sympathetic nerves in the development of mild DOCA-salt hypertension.
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Splanchnic sympathetic nerves in the development of mild DOCA-salt hypertension.

机译：内脏交感神经在轻度DOCA盐高血压的发展中。

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摘要

We previously reported that mild deoxycorticosterone acetate (DOCA)-salt hypertension develops in the absence of generalized sympathoexcitation. However, sympathetic nervous system activity (SNA) is regionally heterogeneous, so we began to investigate the role of sympathetic nerves to specific regions. Our first study on that possibility revealed no contribution of renal nerves to hypertension development. The splanchnic sympathetic nerves are implicated in blood pressure (BP) regulation because splanchnic denervation effectively lowers BP in human hypertension. Here we tested the hypothesis that splanchnic SNA contributes to the development of mild DOCA-salt hypertension. Splanchnic denervation was achieved by celiac ganglionectomy (CGX) in one group of rats while another group underwent sham surgery (SHAM-GX). After DOCA treatment (50 mg/kg) in rats with both kidneys intact, CGX rats exhibited a significantly attenuated increase in BP compared with SHAM-GX rats (15.6 +/- 2.2 vs. 25.6 +/- 2.2 mmHg, day 28 after DOCA treatment). In other rats, whole body norepinephrine (NE) spillover, measured to determine if CGX attenuated hypertension development by reducing global SNA, was not found to be different between SHAM-GX and CGX rats. In a third group, nonhepatic splanchnic NE spillover was measured as an index of splanchnic SNA, but this was not different between SHAM (non-DOCA-treated) and DOCA rats during hypertension development. In a final group, CGX effectively abolished nonhepatic splanchnic NE spillover. These data suggest that an intact splanchnic innervation is necessary for mild DOCA-salt hypertension development but not increased splanchnic SNA or NE release. Increased splanchnic vascular reactivity to NE during DOCA-salt treatment is one possible explanation.
机译：我们先前曾报道过轻度的脱氧皮质酮醋酸盐（DOCA）-盐高血压在没有普遍的交感神经兴奋的情况下发展。但是，交感神经系统活动（SNA）在区域上是异质的，因此我们开始研究交感神经在特定区域的作用。我们对此可能性的第一个研究表明，肾脏神经对高血压的发展没有任何贡献。内脏交感神经牵涉血压（BP）调节，因为内脏神经支配能有效降低人高血压的血压。在这里，我们测试了内脏SNA有助于轻度DOCA盐高血压发展的假说。一组大鼠通过腹腔神经节切除术（CGX）实现了内脏神经支配，而另一组则进行了假手术（SHAM-GX）。在DOCA处理（50 mg / kg）的两个肾脏都完整的大鼠中，与SHAM-GX大鼠相比，CGX大鼠的BP血压显着降低（DOCA后28天，分别为15.6 +/- 2.2和25.6 +/- 2.2 mmHg。治疗）。在其他大鼠中，未发现全身去甲肾上腺素（NE）外溢在SHAM-GX和CGX大鼠之间没有区别，该溢出用于确定CGX是否通过降低整体SNA来减轻高血压的发展。在第三组中，非肝内脏NE溢出被测量为内脏SNA的指标，但是在高血压发展过程中，SHAM（未经DOCA处理）和DOCA大鼠之间没有差异。在最后一组中，CGX有效消除了非肝内脏NE的外溢。这些数据表明，完整的内脏神经支配对于轻度DOCA-盐高血压的发展是必要的，但不需要增加内脏SNA或NE的释放。在DOCA-盐治疗期间内脏血管对NE的反应性增加是一种可能的解释。

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