• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Hydration status affects urea transport across rat urothelia.
【24h】

Hydration status affects urea transport across rat urothelia.

机译：水合状态影响尿素跨大鼠尿路上皮的运输。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although mammalian urinary tract epithelium (urothelium) is generally considered impermeable to water and solutes, recent data suggest that urine constituents may be reabsorbed during urinary tract transit and storage. To study water and solute transport across the urothelium in an in vivo rat model, we instilled urine (obtained during various rat hydration conditions) into isolated in situ rat bladders and, after a 1-h dwell, retrieved the urine and measured the differences in urine volume and concentration and total quantity of urine urea nitrogen and creatinine between instilled and retrieved urine in rat groups differing by hydration status. Although urine volume did not change >1.9% in any group, concentration (and quantity) of urine urea nitrogen in retrieved urine fell significantly (indicating reabsorption of urea across bladder urothelia), by a mean of 18% (489 mg/dl, from an instilled 2,658 mg/dl) in rats receiving ad libitum water and by a mean of 39% (2,544 mg/dl, from an instilled 6,204 mg/dl) in water-deprived rats, but did not change (an increase of 15 mg/dl, P = not significant, from an instilled 300 mg/dl) in a water-loaded rat group. Two separate factors affected urea nitrogen reabsorption rates, a urinary factor related to hydration status, likely the concentration of urea nitrogen in the instilled urine, and a bladder factor(s), also dependent on the animal's state of hydration. Urine creatinine was also absorbed during the bladder dwell, and hydration group effects on the concentration and quantity of creatinine reabsorbed were qualitatively similar to the hydration group effect on urea transport. These findings support the notion(s) that urinary constituents may undergo transport across urinary tract epithelia, that such transport may be physiologically regulated, and that urine is modified during transit and storage through the urinary tract.
机译：尽管通常认为哺乳动物尿道上皮（尿道上皮）不透水和溶质，但最近的数据表明，尿成分可能在尿路转运和储存过程中被重新吸收。为了研究在体内大鼠模型中水和溶质在尿路上皮中的运输，我们将尿液（在各种大鼠水合作用条件下获得）注入到原位大鼠膀胱中，并放置1小时后取回尿液并测量在大鼠组中，滴注和回收尿液之间的尿液量，尿素氮和肌酐的浓度和总量因水合状态而异。尽管任何一组的尿量变化均不大于1.9％，但尿液中尿素氮的浓度（和数量）显着下降（表明尿素在膀胱尿路上皮中的重吸收），平均降低了18％（489 mg / dl）在接受自由饮水的大鼠中滴注了2,658 mg / dl，在缺水的大鼠中平均滴注了39％（从滴注的6,204 mg / dl中吸取了2,544 mg / dl），但没有变化（增加了15 mg / dl，P =不显着，在水负荷大鼠组中滴注300 mg / dl。有两个独立的因素影响尿素氮的重吸收率，一个与水合作用状态有关的泌尿因素，可能是滴入尿液中尿素氮的浓度，另一个与膀胱的因素有关，这也取决于动物的水合作用状态。尿液肌酐在膀胱停留期间也被吸收，水合组对再吸收肌酐浓度和数量的影响在质量上与水合组对尿素转运的影响相似。这些发现支持以下观念：尿成分可以通过尿道上皮运输，可以在生理上调节这种运输，并且在通过尿路运输和储存期间尿液被修饰。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号