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首页> 外文期刊>American Journal of Physiology >Evidence for greater burden of peripheral arterial disease in lower extremity arteries of spinal cord-injured individuals.
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Evidence for greater burden of peripheral arterial disease in lower extremity arteries of spinal cord-injured individuals.

机译：脊髓损伤个体下肢动脉周围动脉疾病负担增加的证据。

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Spinal cord injury leads to increased risk for cardiovascular disease and results in greater risk of death. Subclinical markers of atherosclerosis have been reported in carotid arteries of spinal cord-injured individuals (SCI), but the development of lower extremity peripheral arterial disease (PAD) has not been investigated in this population. The purpose of this study was to determine the effect of spinal cord injury on ankle-brachial index (ABI) and intima-media thickness (IMT) of upper-body and lower-extremity arteries. We hypothesized that the aforementioned measures of lower-extremity PAD would be worsened in SCI compared with controls and that regular participation in endurance exercise would improve these in both groups. To test these hypotheses, ABI and IMT were determined in 105 SCI and compared with 156 able-bodied controls with groups further subdivided into physically active and sedentary. ABIs were significantly lower in SCI versus controls (0.96 +/- 0.12 vs. 1.06 +/- 0.07, P < 0.001), indicating a greater burden of lower-extremity PAD. Upper-body IMTs were similar for brachial and carotid arteries in controls versus SCI. Lower extremity IMTs revealed similar thicknesses for both superficial femoral and popliteal arteries, but when normalized for artery diameter, individuals with SCI had greater IMT than controls in the superficial femoral (0.094 +/- 0.03 vs. 0.073 +/- 0.02 mm/mm lumen diameter, P < 0.01) and popliteal (0.117 +/- 0.04 vs. 0.091 +/- 0.02 mm/mm lumen diameter, P < 0.01) arteries. The ABI and normalized IMT of SCI compared with controls indicate that subclinical measures of lower-extremity PAD are worsened in individuals with SCI. These findings should prompt physicians to consider using the ABI as a screening method to detect lower-extremity PAD in SCI.
机译：脊髓损伤导致心血管疾病的风险增加，并导致更大的死亡风险。脊髓损伤个体（SCI）的颈动脉中已报告了动脉粥样硬化的亚临床标志物，但尚未对该人群的下肢周围动脉疾病（PAD）的发展进行研究。这项研究的目的是确定脊髓损伤对上臂和下肢动脉的踝臂指数（ABI）和内膜中层厚度（IMT）的影响。我们假设，与对照组相比，SCI的上述下肢PAD措施会恶化，并且定期参加耐力运动将在两组中都改善这些情况。为了检验这些假设，在105 SCI中确定了ABI和IMT，并与156个身体健壮的对照组进行了比较，并进一步将其分为运动活跃和久坐不动的人群。与对照相比，SCI中的ABI显着降低（0.96 +/- 0.12 vs. 1.06 +/- 0.07，P <0.001），表明下肢PAD负担更大。与SCI相比，上臂IMT与肱动脉和颈动脉的IMT相似。下肢IMT显示股浅动脉和pop动脉的厚度相似，但是当将动脉直径标准化后，SCI患者的股骨内膜IMT比对照值高（0.094 +/- 0.03 vs. 0.073 +/- 0.02 mm / mm内腔动脉直径（P <0.01）和pop动脉（0.117 +/- 0.04与0.091 +/- 0.02 mm / mm内腔直径，P <0.01）。与对照相比，SCI的ABI和IMT标准化表明在SCI患者中，下肢PAD的亚临床测量指标恶化。这些发现应促使医生考虑使用ABI作为筛查SCI下肢PAD的方法。

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