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首页> 外文期刊>American Journal of Physiology >Role of Y 2 receptors in the regulation of gastric tone in rats
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Role of Y 2 receptors in the regulation of gastric tone in rats

机译：Y 2受体在大鼠胃音调节中的作用

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We set out to determine the effect of peptide YY 3-36 (PYY 3-36) on the gastric muscle tone in conscious rats by measuring intragastric pressure (IGP) during intragastric nutrient drink infusion. After an overnight fast, a chronically implanted gastric fistula was connected to a custom-made nutrient drink infusion system and a catheter to measure IGP. IGP was measured before and during the infusion of a nutrient drink (Nutridrink; 0.5 ml/min) until 10 ml was infused. Rats were treated with PYY 3-36 (0, 33, and 100 pmol??kg -1??min -1) in combination with a subcutaneous injection of the Y 2 receptor antagonists JNJ31020028 (10 mg/kg) or BIIE0246 (2 mg/kg). Experiments were also performed after subdiaphragmatic vagotomy and after pretreatment with 3 ml of nutrient drink (to mimic a fed state). IGP was compared as the average IGP during nutrient infusion, represented as means ?? SE and compared using ANOVA. PYY 3-36 dose dependently increased the IGP during nutrient infusion (4.7 ?? 0.3, 5.7 ?? 0.5 and 7.3 ?? 0.7 mmHg; P 0.01) while JNJ31020028 and BIIE0246 could block this increase [4.4 ?? 0.5 (P 0.001) and 4.8 ?? 0.4 (P 0.05) mmHg, respectively]. Also in vagotomized rats, PYY 3-36 was able to significantly increase the IGP during, an effect attenuated by JNJ31020028. BIIE0246 and JNJ31020028 were not able to decrease the IGP when no PYY 3-36 was administered. PYY 3-36 increased gastric tone through an Y 2 receptor-mediated mechanism that does not involve the vagus nerve. Y 2 receptor antagonists were not able to decrease gastric tone without exogenous administration of PYY 3-36, indicating that Y 2 receptors do not play a crucial role in the determination of gastric tone in physiological conditions. ? 2012 the American Physiological Society.
机译：我们着手通过测量灌胃营养液期间的胃内压力（IGP），来确定YY 3-36肽（PYY 3-36）对清醒大鼠胃肌张力的影响。过夜禁食后，将慢性植入的胃瘘与定制的营养饮料输注系统和导管相连接，以测量IGP。在注入营养饮料之前（Nutridrink; 0.5 ml / min）直到注入10 ml之前和之中，测量IGP。用PYY 3-36（0、33和100 pmol ?? kg -1 ?? min -1）联合皮下注射Y 2受体拮抗剂JNJ31020028（10 mg / kg）或BIIE0246（2）治疗大鼠毫克/公斤）。在dia下迷走神经切断术之后和用3 ml营养饮料（模拟进食状态）进行预处理后，还进行了实验。将IGP作为营养素注入期间的平均IGP进行比较，以平均值??表示。 SE并使用ANOVA进行比较。在营养物注入过程中，PYY 3-36剂量依赖性地增加了IGP（4.7 ?? 0.3、5.7 ?? 0.5和7.3 ?? 0.7 mmHg; P <0.01），而JNJ31020028和BIIE0246可以阻止这种增加[4.4？ 0.5（P <0.001）和4.8 ?? 0.4（P <0.05）mmHg]。同样在迷走神经切断的大鼠中，PYY 3-36能够显着增加IGP的水平，这一作用被JNJ31020028减弱了。当未施用PYY 3-36时，BIIE0246和JNJ31020028无法降低IGP。 PYY 3-36通过不涉及迷走神经的Y 2受体介导的机制增加了胃音。 Y 2受体拮抗剂在不外源给予PYY 3-36的情况下不能降低胃音，表明Y 2受体在生理条件下确定胃音方面没有关键作用。 ？ 2012年美国生理学会。

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