...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Analytical chemistry >Chiral Sensing Using a Complementary Metal-Oxide Semiconductor-Integrated Three-Transducer Microsensor System
【24h】

Chiral Sensing Using a Complementary Metal-Oxide Semiconductor-Integrated Three-Transducer Microsensor System

机译：使用互补的金属氧化物半导体集成的三传感器微传感器系统进行手性传感

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Different chiral cyclodextrin derivatives were dissolved in a polysiloxane matrix and have been used as sensitive coatings on a three-transducer microsystem including a calorimetric, a mass-sensitive, and a capacitive chemical sensor. Upon exposure to chiral analytes, such as methyl lactate and methyl-2-chloropropionate, all three transducers showed distinct chiral discrimination of these analytes. The signals were found to constitute a convolution of sorption thermodynamics and transducer-specific contributions, which included, in the case of the capacitive sensor, molecular orientation effects so that even opposite-sign signals for the two enantiomers resulted. The sensor response curves of all three transducers could be explained and fitted by applying a model that essentially implies the superposition of a Langmuir isotherm representing specific interactions, predominant at low concentrations, and a Henry isotherm for nonspecific physisorption. The results disclosed here show that, on the one hand, sensor techniques can be used to reveal details of enantioselective analyte-receptor or analyte-matrix interactions and that, on the other hand, sensors may provide an even more pronounced chiral discrimination ("discrimination enhancement") with respect to sorption-thermodynamics-determined gas chromatography as a consequence of the transducer-specific signal contributions.
机译：将不同的手性环糊精衍生物溶解在聚硅氧烷基质中，并已用作三传感器微系统上的敏感涂层，该三传感器微系统包括量热，质量敏感和电容化学传感器。暴露于手性分析物（如乳酸甲酯和-2-氯丙酸甲酯）后，所有三个换能器均表现出对这些分析物的独特手性区分。发现这些信号构成了吸附热力学和传感器特有作用的卷积，对于电容式传感器而言，这些信号包括分子取向效应，因此甚至产生两种对映体的相反信号。可以通过应用一个模型来解释和拟合所有三个换能器的传感器响应曲线，该模型本质上隐含代表特定相互作用的Langmuir等温线的叠加（主要是在低浓度时）和非特异性物理吸附的Henry等温线。这里公开的结果表明，一方面，传感器技术可用于揭示对映选择性分析物-受体或分析物-基质相互作用的细节，另一方面，传感器可提供更明显的手性鉴别（“鉴别”）。换热器特定的信号贡献的结果”）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号