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首页> 外文期刊>Analytical chemistry >Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy
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Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy

机译：高分辨率高分辨率魔角旋转化学交换饱和转移Z光谱的组织表征

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摘要

Chemical exchange saturation transfer (CEST) provides sensitive magnetic resonance (MR) contrast for probing dilute compounds via exchangeable protons, serving as an emerging molecular imaging methodology. CEST Z-spectrum is often acquired by sweeping radiofrequency saturation around bulk water resonance, offset by offset, to detect CEST effects at characteristic chemical shift offsets, which requires prolonged acquisition time. Herein, combining high-resolution magic angle spinning (HRMAS) with concurrent application of gradient and rf saturation to achieve fast Z-spectral acquisition, we demonstrated the feasibility of fast quantitative HRMAS CEST Z-spectroscopy. The concept was validated with phantoms, which showed excellent agreement with results obtained from conventional HRMAS MR spectroscopy (MRS). We further utilized the HRMAS Z-spectroscopy for fast ex vivo quantification of ischemic injury with rodent brain tissues after ischemic stroke. This method allows rapid and quantitative CEST characterization of biological tissues and shows potential for a host of biomedical applications.
机译：化学交换饱和转移（CEST）为通过可交换质子探测稀化合物提供灵敏的磁共振（MR）对比度，是一种新兴的分子成像方法。 CEST Z光谱通常是通过在大量水共振附近扫描射频饱和度（逐偏移量）来获取的，以检测特征性化学位移偏移量上的CEST效应，这需要较长的获取时间。在本文中，结合高分辨率魔角旋转（HRMAS）与同时应用梯度和rf饱和度以实现快速Z光谱采集，我们证明了快速定量HRMAS CEST Z光谱的可行性。幻影验证了该概念，该幻影与常规HRMAS MR光谱学（MRS）获得的结果非常吻合。我们进一步利用HRMAS Z光谱对离体中风后啮齿动物脑组织的缺血性损伤进行快速离体定量。这种方法可以对生物组织进行快速定量的CEST表征，并显示出在许多生物医学应用中的潜力。

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