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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Effect of Silibinin in Enhancing Toxicity of Temozolomide and Etoposide in p53 and PTEN-mutated Resistant Glioma Cell Lines
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The Effect of Silibinin in Enhancing Toxicity of Temozolomide and Etoposide in p53 and PTEN-mutated Resistant Glioma Cell Lines

机译：水飞蓟宾对增强p53和PTEN突变的耐药胶质瘤细胞系中替莫唑胺和依托泊苷毒性的作用

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摘要

Glioblastoma multiforme (GBM) is an intractable brain tumor, associated with poor prognosis and low survival rate. Combination therapy such as surgery, radiotherapy and temozolomide is considered standard in overcoming this aggressive cancer, despite poor prognosis. There is a need to identify potential agents, which may augment the chemotherapeutic effects of standard drugs such as temozolomide. In this project, we evaluated the effects of silibinin, a natural plant component of milk thistle seeds, to potentiate toxic effects of chemotherapy drugs such as temozolomide, etoposide and irinotecan on LN229, U87 and A172 (P53 and phosphatase and tensin homolog (PTEN) -tumor suppressor-mutated) glioma cell lines. Data from this work suggest that silibinin was effective in potentiating the cytotoxic efficacy of temozolomide in LN229, U87 and A172 cells. While silibinin reduced survivin protein expression only in LN229 cells, its ability to potentiate cytotoxicity of chemotherapy drugs occurred irrespective of survivin protein levels. The data also demonstrated that silibinin potentiated the effect of etoposide and but not irinotecan in LN229 cells. Future research will be required to evaluate the in vivo efficacy of silibinin to delineate its mechanism of action and its ability to cross the blood-brain barrier.
机译：多形胶质母细胞瘤（GBM）是一种顽固性脑肿瘤，与预后不良和低生存率相关。尽管预后较差，但如手术，放疗和替莫唑胺等联合疗法被认为是克服这种侵袭性癌症的标准方法。需要确定可能增强标准药物（如替莫唑胺）的化学治疗作用的潜在药物。在这个项目中，我们评估了水飞蓟素（一种水飞蓟种子的天然植物成分）对替莫唑胺，依托泊苷和伊立替康等化学药物对LN229，U87和A172（P53和磷酸酶和张力蛋白同源物（PTEN）的毒性作用）的作用。肿瘤抑制基因突变的神经胶质瘤细胞系。这项工作的数据表明，水飞蓟宾可有效增强替莫唑胺在LN229，U87和A172细胞中的细胞毒性。尽管水飞蓟宾仅在LN229细胞中降低生存素蛋白的表达，但其增强化疗药物的细胞毒性的能力却与生存素蛋白的水平无关。数据还表明，水飞蓟宾增强了依托泊苷的作用，但不能增强伊立替康对LN229细胞的作用。需要进一步的研究来评估水飞蓟宾的体内功效，以描述其作用机理及其穿越血脑屏障的能力。

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