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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >FOXD1 Expression Is Associated with Poor Prognosis in Non-small Cell Lung Cancer
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FOXD1 Expression Is Associated with Poor Prognosis in Non-small Cell Lung Cancer

机译:FOXD1表达与非小细胞肺癌的不良预后相关。

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摘要

Aim: Clinical microarray datasets were analyzed to search for new therapeutic targets and prognostic markers of non-small cell lung cancer (NSCLC). Materials and Methods: Microarray datasets from 90 lung cancer specimens, were analyzed with focus on the FOXD1 gene. Levels of FOXDI mRNA were assessed in lung cancer cell lines and these levels were correlated with survival. Results: FOXD1-knockdown led to suppression of cell proliferation. Moreover, patients with high FOXDI expression survived for a significantly shorter time than those with low FOXDI expression. Conclusion: The expression status of FOXD1 is a novel prognostic factor and may lead to new treatment strategies for NSCLC.
机译:目的:分析临床微阵列数据集以寻找新的治疗靶点和非小细胞肺癌(NSCLC)的预后标志物。材料和方法:分析了90个肺癌标本的微阵列数据集,重点是FOXD1基因。在肺癌细胞系中评估了FOXDI mRNA的水平,这些水平与存活率相关。结果:FOXD1组合式抑制细胞增殖。此外,FOXDI表达高的患者比FOXDI表达低的患者生存时间短得多。结论:FOXD1的表达状态是一种新的预后因素,可能导致新的NSCLC治疗策略。

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